IKZF1 deletions associate with CRLF2 overexpression leading to a poor prognosis in B-cell precursor acute lymphoblastic leukaemia

Cytokine Receptor-Like Factor 2 (CRLF2) overexpression occurs in 5-15% of B-cell precursor acute lymphoblastic leukaemia (B-ALL). In ∼50% of these cases, the mechanisms underlying this dysregulation are unknown. IKAROS Family Zinc Finger 1 (IKZF1) is a possible candidate to play a role in this dysre...

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Detalles Bibliográficos
Autores principales: Maciel, Ana Luiza Tardem, Barbosa, Thayana da Conceição, Blunck, Caroline Barbieri, Wolch, Karolyne, Machado, Amanda de Albuquerque Lopes, da Costa, Elaine Sobral, Bergier, Lavínia Lustosa, Schramm, Márcia Trindade, Ikoma-Coltutato, Maura Rosane Valério, Lins, Mecneide Mendes, Aguiar, Thais Ferraz, Mansur, Marcela Braga, Emerenciano, Mariana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633010/
https://www.ncbi.nlm.nih.gov/pubmed/34826720
http://dx.doi.org/10.1016/j.tranon.2021.101291

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