Co-expression of Myoepithelial and Melanocytic Features in Carcinoma Ex Pleomorphic Adenoma

The presence of melanin pigment and melanocytic markers expression have been rarely reported in salivary gland tumors. Herein, two cases of carcinoma arising in pleomorphic adenoma of the parotid gland and showing diffuse expression of myoepithelial and melanocytic markers are described. The clinica...

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Detalles Bibliográficos
Autores principales: Ricci, Costantino, Chiarucci, Federico, Ambrosi, Francesca, Balbi, Tiziana, Corti, Barbara, Piccin, Ottavio, Pasquini, Ernesto, Foschini, Maria Pia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633150/
https://www.ncbi.nlm.nih.gov/pubmed/33591488
http://dx.doi.org/10.1007/s12105-021-01299-4
Descripción
Sumario:The presence of melanin pigment and melanocytic markers expression have been rarely reported in salivary gland tumors. Herein, two cases of carcinoma arising in pleomorphic adenoma of the parotid gland and showing diffuse expression of myoepithelial and melanocytic markers are described. The clinical-pathological clues useful in the differential diagnosis with melanoma are discussed. In addition, a review of the pertinent literature is also proposed, discussing the pathologic mechanisms potentially involved in this phenomenon. SUPPLEMENTARY INFORMATION: The online version of this article (10.1007/s12105-021-01299-4) contains supplementary material, which is available to authorized users.

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