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Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits

We develop a Bayesian model (BayesRR-RC) that provides robust SNP-heritability estimation, an alternative to marker discovery, and accurate genomic prediction, taking 22 seconds per iteration to estimate 8.4 million SNP-effects and 78 SNP-heritability parameters in the UK Biobank. We find that only...

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Detalles Bibliográficos
Autores principales:	Patxot, Marion, Banos, Daniel Trejo, Kousathanas, Athanasios, Orliac, Etienne J., Ojavee, Sven E., Moser, Gerhard, Holloway, Alexander, Sidorenko, Julia, Kutalik, Zoltan, Mägi, Reedik, Visscher, Peter M., Rönnegård, Lars, Robinson, Matthew R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633298/ https://www.ncbi.nlm.nih.gov/pubmed/34848700 http://dx.doi.org/10.1038/s41467-021-27258-9

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