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Immunomodulation for the Treatment of Chronic Chagas Disease Cardiomyopathy: A New Approach to an Old Enemy
Chagas disease is a parasitic infection caused by the intracellular protozoan Trypanosoma cruzi. Chronic Chagas cardiomyopathy (CCC) is the most severe manifestation of the disease, developed by approximately 20-40% of patients and characterized by occurrence of arrhythmias, heart failure and death....
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633308/ https://www.ncbi.nlm.nih.gov/pubmed/34869068 http://dx.doi.org/10.3389/fcimb.2021.765879 |
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author | Santos, Emanuelle de Souza Silva, Dahara Keyse Carvalho dos Reis, Bruna Padilha Zurita Claro Barreto, Breno Cardim Cardoso, Carine Machado Azevedo Ribeiro dos Santos, Ricardo Meira, Cássio Santana Soares, Milena Botelho Pereira |
author_facet | Santos, Emanuelle de Souza Silva, Dahara Keyse Carvalho dos Reis, Bruna Padilha Zurita Claro Barreto, Breno Cardim Cardoso, Carine Machado Azevedo Ribeiro dos Santos, Ricardo Meira, Cássio Santana Soares, Milena Botelho Pereira |
author_sort | Santos, Emanuelle de Souza |
collection | PubMed |
description | Chagas disease is a parasitic infection caused by the intracellular protozoan Trypanosoma cruzi. Chronic Chagas cardiomyopathy (CCC) is the most severe manifestation of the disease, developed by approximately 20-40% of patients and characterized by occurrence of arrhythmias, heart failure and death. Despite having more than 100 years of discovery, Chagas disease remains without an effective treatment, especially for patients with CCC. Since the pathogenesis of CCC depends on a parasite-driven systemic inflammatory profile that leads to cardiac tissue damage, the use of immunomodulators has become a rational alternative for the treatment of CCC. In this context, different classes of drugs, cell therapies with dendritic cells or stem cells and gene therapy have shown potential to modulate systemic inflammation and myocarditis in CCC models. Based on that, the present review provides an overview of current reports regarding the use of immunomodulatory agents in treatment of CCC, bringing the challenges and future directions in this field. |
format | Online Article Text |
id | pubmed-8633308 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86333082021-12-02 Immunomodulation for the Treatment of Chronic Chagas Disease Cardiomyopathy: A New Approach to an Old Enemy Santos, Emanuelle de Souza Silva, Dahara Keyse Carvalho dos Reis, Bruna Padilha Zurita Claro Barreto, Breno Cardim Cardoso, Carine Machado Azevedo Ribeiro dos Santos, Ricardo Meira, Cássio Santana Soares, Milena Botelho Pereira Front Cell Infect Microbiol Cellular and Infection Microbiology Chagas disease is a parasitic infection caused by the intracellular protozoan Trypanosoma cruzi. Chronic Chagas cardiomyopathy (CCC) is the most severe manifestation of the disease, developed by approximately 20-40% of patients and characterized by occurrence of arrhythmias, heart failure and death. Despite having more than 100 years of discovery, Chagas disease remains without an effective treatment, especially for patients with CCC. Since the pathogenesis of CCC depends on a parasite-driven systemic inflammatory profile that leads to cardiac tissue damage, the use of immunomodulators has become a rational alternative for the treatment of CCC. In this context, different classes of drugs, cell therapies with dendritic cells or stem cells and gene therapy have shown potential to modulate systemic inflammation and myocarditis in CCC models. Based on that, the present review provides an overview of current reports regarding the use of immunomodulatory agents in treatment of CCC, bringing the challenges and future directions in this field. Frontiers Media S.A. 2021-11-12 /pmc/articles/PMC8633308/ /pubmed/34869068 http://dx.doi.org/10.3389/fcimb.2021.765879 Text en Copyright © 2021 Santos, Silva, Reis, Barreto, Cardoso, Ribeiro dos Santos, Meira and Soares https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Santos, Emanuelle de Souza Silva, Dahara Keyse Carvalho dos Reis, Bruna Padilha Zurita Claro Barreto, Breno Cardim Cardoso, Carine Machado Azevedo Ribeiro dos Santos, Ricardo Meira, Cássio Santana Soares, Milena Botelho Pereira Immunomodulation for the Treatment of Chronic Chagas Disease Cardiomyopathy: A New Approach to an Old Enemy |
title | Immunomodulation for the Treatment of Chronic Chagas Disease Cardiomyopathy: A New Approach to an Old Enemy |
title_full | Immunomodulation for the Treatment of Chronic Chagas Disease Cardiomyopathy: A New Approach to an Old Enemy |
title_fullStr | Immunomodulation for the Treatment of Chronic Chagas Disease Cardiomyopathy: A New Approach to an Old Enemy |
title_full_unstemmed | Immunomodulation for the Treatment of Chronic Chagas Disease Cardiomyopathy: A New Approach to an Old Enemy |
title_short | Immunomodulation for the Treatment of Chronic Chagas Disease Cardiomyopathy: A New Approach to an Old Enemy |
title_sort | immunomodulation for the treatment of chronic chagas disease cardiomyopathy: a new approach to an old enemy |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633308/ https://www.ncbi.nlm.nih.gov/pubmed/34869068 http://dx.doi.org/10.3389/fcimb.2021.765879 |
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