Cargando…

Natural products: potential treatments for cisplatin-induced nephrotoxicity

Cisplatin is a clinically advanced and highly effective anticancer drug used in the treatment of a wide variety of malignancies, such as head and neck, lung, testis, ovary, breast cancer, etc. However, it has only a limited use in clinical practice due to its severe adverse effects, particularly nep...

Descripción completa

Detalles Bibliográficos
Autores principales: Fang, Chun-yan, Lou, Da-yong, Zhou, Li-qin, Wang, Jin-cheng, Yang, Bo, He, Qiao-jun, Wang, Jia-jia, Weng, Qin-jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633358/
https://www.ncbi.nlm.nih.gov/pubmed/33750909
http://dx.doi.org/10.1038/s41401-021-00620-9
_version_ 1784607910167314432
author Fang, Chun-yan
Lou, Da-yong
Zhou, Li-qin
Wang, Jin-cheng
Yang, Bo
He, Qiao-jun
Wang, Jia-jia
Weng, Qin-jie
author_facet Fang, Chun-yan
Lou, Da-yong
Zhou, Li-qin
Wang, Jin-cheng
Yang, Bo
He, Qiao-jun
Wang, Jia-jia
Weng, Qin-jie
author_sort Fang, Chun-yan
collection PubMed
description Cisplatin is a clinically advanced and highly effective anticancer drug used in the treatment of a wide variety of malignancies, such as head and neck, lung, testis, ovary, breast cancer, etc. However, it has only a limited use in clinical practice due to its severe adverse effects, particularly nephrotoxicity; 20%–35% of patients develop acute kidney injury (AKI) after cisplatin administration. The nephrotoxic effect of cisplatin is cumulative and dose dependent and often necessitates dose reduction or withdrawal. Recurrent episodes of AKI result in impaired renal tubular function and acute renal failure, chronic kidney disease, uremia, and hypertensive nephropathy. The pathophysiology of cisplatin-induced AKI involves proximal tubular injury, apoptosis, oxidative stress, inflammation, and vascular injury in the kidneys. At present, there are no effective drugs or methods for cisplatin-induced kidney injury. Recent in vitro and in vivo studies show that numerous natural products (flavonoids, saponins, alkaloids, polysaccharide, phenylpropanoids, etc.) have specific antioxidant, anti-inflammatory, and anti-apoptotic properties that regulate the pathways associated with cisplatin-induced kidney damage. In this review we describe the molecular mechanisms of cisplatin-induced nephrotoxicity and summarize recent findings in the field of natural products that undermine these mechanisms to protect against cisplatin-induced kidney damage and provide potential strategies for AKI treatment.
format Online
Article
Text
id pubmed-8633358
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Springer Nature Singapore
record_format MEDLINE/PubMed
spelling pubmed-86333582021-12-15 Natural products: potential treatments for cisplatin-induced nephrotoxicity Fang, Chun-yan Lou, Da-yong Zhou, Li-qin Wang, Jin-cheng Yang, Bo He, Qiao-jun Wang, Jia-jia Weng, Qin-jie Acta Pharmacol Sin Review Article Cisplatin is a clinically advanced and highly effective anticancer drug used in the treatment of a wide variety of malignancies, such as head and neck, lung, testis, ovary, breast cancer, etc. However, it has only a limited use in clinical practice due to its severe adverse effects, particularly nephrotoxicity; 20%–35% of patients develop acute kidney injury (AKI) after cisplatin administration. The nephrotoxic effect of cisplatin is cumulative and dose dependent and often necessitates dose reduction or withdrawal. Recurrent episodes of AKI result in impaired renal tubular function and acute renal failure, chronic kidney disease, uremia, and hypertensive nephropathy. The pathophysiology of cisplatin-induced AKI involves proximal tubular injury, apoptosis, oxidative stress, inflammation, and vascular injury in the kidneys. At present, there are no effective drugs or methods for cisplatin-induced kidney injury. Recent in vitro and in vivo studies show that numerous natural products (flavonoids, saponins, alkaloids, polysaccharide, phenylpropanoids, etc.) have specific antioxidant, anti-inflammatory, and anti-apoptotic properties that regulate the pathways associated with cisplatin-induced kidney damage. In this review we describe the molecular mechanisms of cisplatin-induced nephrotoxicity and summarize recent findings in the field of natural products that undermine these mechanisms to protect against cisplatin-induced kidney damage and provide potential strategies for AKI treatment. Springer Nature Singapore 2021-03-09 2021-12 /pmc/articles/PMC8633358/ /pubmed/33750909 http://dx.doi.org/10.1038/s41401-021-00620-9 Text en © The Author(s) 2021, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Fang, Chun-yan
Lou, Da-yong
Zhou, Li-qin
Wang, Jin-cheng
Yang, Bo
He, Qiao-jun
Wang, Jia-jia
Weng, Qin-jie
Natural products: potential treatments for cisplatin-induced nephrotoxicity
title Natural products: potential treatments for cisplatin-induced nephrotoxicity
title_full Natural products: potential treatments for cisplatin-induced nephrotoxicity
title_fullStr Natural products: potential treatments for cisplatin-induced nephrotoxicity
title_full_unstemmed Natural products: potential treatments for cisplatin-induced nephrotoxicity
title_short Natural products: potential treatments for cisplatin-induced nephrotoxicity
title_sort natural products: potential treatments for cisplatin-induced nephrotoxicity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633358/
https://www.ncbi.nlm.nih.gov/pubmed/33750909
http://dx.doi.org/10.1038/s41401-021-00620-9
work_keys_str_mv AT fangchunyan naturalproductspotentialtreatmentsforcisplatininducednephrotoxicity
AT loudayong naturalproductspotentialtreatmentsforcisplatininducednephrotoxicity
AT zhouliqin naturalproductspotentialtreatmentsforcisplatininducednephrotoxicity
AT wangjincheng naturalproductspotentialtreatmentsforcisplatininducednephrotoxicity
AT yangbo naturalproductspotentialtreatmentsforcisplatininducednephrotoxicity
AT heqiaojun naturalproductspotentialtreatmentsforcisplatininducednephrotoxicity
AT wangjiajia naturalproductspotentialtreatmentsforcisplatininducednephrotoxicity
AT wengqinjie naturalproductspotentialtreatmentsforcisplatininducednephrotoxicity