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Drug evaluation based on phosphomimetic PDHA1 reveals the complexity of activity-related cell death in A549 non-small cell lung cancer cells

Cancer cells predominantly generate energy via glycolysis, even in the presence of oxygen, to support abnormal cell proliferation. Suppression of PDHA1 by PDK1 prevents the conversion of cytoplasmic pyruvate into Acetyl-CoA. Several PDK inhibitors have been identified, but their clinical application...

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Detalles Bibliográficos
Autores principales:	Jin, Ling, Cho, Minkyoung, Kim, Bo-Sung, Han, Jung Ho, Park, Sungmi, Lee, In-Kyu, Ryu, Dongryeol, Kim, Jae Ho, Bae, Sung-Jin, Ha, Ki-Tae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Biochemistry and Molecular Biology 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633525/ https://www.ncbi.nlm.nih.gov/pubmed/34488935 http://dx.doi.org/10.5483/BMBRep.2021.54.11.101

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