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Designer proteins that competitively inhibit Gα(q) by targeting its effector site

During signal transduction, the G protein, Gα(q), binds and activates phospholipase C-β isozymes. Several diseases have been shown to manifest upon constitutively activating mutation of Gα(q), such as uveal melanoma. Therefore, methods are needed to directly inhibit Gα(q). Previously, we demonstrate...

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Detalles Bibliográficos
Autores principales:	Hussain, Mahmud, Cummins, Matthew C., Endo-Streeter, Stuart, Sondek, John, Kuhlman, Brian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633581/ https://www.ncbi.nlm.nih.gov/pubmed/34715131 http://dx.doi.org/10.1016/j.jbc.2021.101348

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