Animal models of brain metastasis

Modeling of metastatic disease in animal models is a critical resource to study the complexity of this multi-step process in a relevant system. Available models of metastatic disease to the brain are still far from ideal but they allow to address specific aspects of the biology or mimic clinically r...

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Detalles Bibliográficos
Autores principales: Miarka, Lauritz, Valiente, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Supplement Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633729/
https://www.ncbi.nlm.nih.gov/pubmed/34859241
http://dx.doi.org/10.1093/noajnl/vdab115
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author Miarka, Lauritz
Valiente, Manuel
author_facet Miarka, Lauritz
Valiente, Manuel
author_sort Miarka, Lauritz
collection PubMed
description Modeling of metastatic disease in animal models is a critical resource to study the complexity of this multi-step process in a relevant system. Available models of metastatic disease to the brain are still far from ideal but they allow to address specific aspects of the biology or mimic clinically relevant scenarios. We not only review experimental models and their potential improvements but also discuss specific answers that could be obtained from them on unsolved aspects of clinical management.
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spelling pubmed-86337292021-12-01 Animal models of brain metastasis Miarka, Lauritz Valiente, Manuel Neurooncol Adv Supplement Articles Modeling of metastatic disease in animal models is a critical resource to study the complexity of this multi-step process in a relevant system. Available models of metastatic disease to the brain are still far from ideal but they allow to address specific aspects of the biology or mimic clinically relevant scenarios. We not only review experimental models and their potential improvements but also discuss specific answers that could be obtained from them on unsolved aspects of clinical management. Oxford University Press 2021-11-27 /pmc/articles/PMC8633729/ /pubmed/34859241 http://dx.doi.org/10.1093/noajnl/vdab115 Text en © The Author(s) 2021. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Supplement Articles
Miarka, Lauritz
Valiente, Manuel
Animal models of brain metastasis
title Animal models of brain metastasis
title_full Animal models of brain metastasis
title_fullStr Animal models of brain metastasis
title_full_unstemmed Animal models of brain metastasis
title_short Animal models of brain metastasis
title_sort animal models of brain metastasis
topic Supplement Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633729/
https://www.ncbi.nlm.nih.gov/pubmed/34859241
http://dx.doi.org/10.1093/noajnl/vdab115
work_keys_str_mv AT miarkalauritz animalmodelsofbrainmetastasis
AT valientemanuel animalmodelsofbrainmetastasis

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