Metallothionein 3-Zinc Axis Suppresses Caspase-11 Inflammasome Activation and Impairs Antibacterial Immunity

Non-canonical inflammasome activation by mouse caspase-11 (or human CASPASE-4/5) is crucial for the clearance of certain gram-negative bacterial infections, but can lead to severe inflammatory damage. Factors that promote non-canonical inflammasome activation are well recognized, but less is known a...

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Detalles Bibliográficos
Autores principales: Chowdhury, Debabrata, Gardner, Jason C., Satpati, Abhijit, Nookala, Suba, Mukundan, Santhosh, Porollo, Aleksey, Landero Figueroa, Julio A., Subramanian Vignesh, Kavitha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633875/
https://www.ncbi.nlm.nih.gov/pubmed/34867993
http://dx.doi.org/10.3389/fimmu.2021.755961

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