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Hypoxia-inducible factor-1β is essential for upregulation of the hypoxia‐induced FLT1 gene in placental trophoblasts

Placental hypoxia and increased levels of maternal blood anti-angiogenic protein, soluble fms-like tyrosine kinase-1 (sFLT1), are associated with the pathogenesis of pre-eclampsia. We have demonstrated that hypoxia-inducible factor (HIF)-2α mediates the upregulation of the hypoxia-induced FLT1 gene...

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Detalles Bibliográficos
Autores principales:	Sasagawa, Tadashi, Nagamatsu, Takeshi, Yanagisawa, Manami, Fujii, Tomoyuki, Shibuya, Masabumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633902/ https://www.ncbi.nlm.nih.gov/pubmed/34665260 http://dx.doi.org/10.1093/molehr/gaab065

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