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Relative associations of abdominal and thigh compositions with cardiometabolic diseases in African Caribbean men

BACKGROUND: Regional body compositions are differentially associated with cardiometabolic risk factors. Simultaneous inclusion of both upper and lower body composition predictors in models is not often done, and studies which do include both measures (1) tend to exclude some tissue(s) of potential m...

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Autores principales: Tilves, Curtis, Zmuda, Joseph M., Kuipers, Allison L., Nair, Sangeeta, Carr, John Jeffrey, Terry, James G., Peddada, Shyamal, Wheeler, Victor, Miljkovic, Iva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633926/
https://www.ncbi.nlm.nih.gov/pubmed/34877013
http://dx.doi.org/10.1002/osp4.529
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author Tilves, Curtis
Zmuda, Joseph M.
Kuipers, Allison L.
Nair, Sangeeta
Carr, John Jeffrey
Terry, James G.
Peddada, Shyamal
Wheeler, Victor
Miljkovic, Iva
author_facet Tilves, Curtis
Zmuda, Joseph M.
Kuipers, Allison L.
Nair, Sangeeta
Carr, John Jeffrey
Terry, James G.
Peddada, Shyamal
Wheeler, Victor
Miljkovic, Iva
author_sort Tilves, Curtis
collection PubMed
description BACKGROUND: Regional body compositions are differentially associated with cardiometabolic risk factors. Simultaneous inclusion of both upper and lower body composition predictors in models is not often done, and studies which do include both measures (1) tend to exclude some tissue(s) of potential metabolic relevance, and (2) have used study populations with underrepresentation of individuals with African ancestries. Further, most body composition analyses do not employ compositional data analytic approaches, which may result in spurious associations. OBJECTIVE: The objective of this analysis was to assess associations of abdominal and thigh adipose (AT) and muscle tissues with hypertension and type 2 diabetes using compositional data analytic methods. RESEARCH DESIGN AND METHODS: This cross‐sectional analysis included 610 African Caribbean men (median age: 62 years; mean BMI: 27.8 kg/m(2)). Abdominal (three components: subcutaneous [ASAT] and visceral [VAT] AT, ‘other’ abdominal tissue) and mid‐thigh (four components: subcutaneous and intermuscular AT, muscle, bone) compositions were measured by computed tomography; additive log ratio transformations were applied to each composition. Regression models were used to simultaneously assess associations of abdominal and thigh component ratios with continuous risk factors (blood pressures, fasting glucose and insulin, HOMA‐IR) and disease categories. RESULTS: A two‐fold increase in ASAT:‘Other’ ratio was associated with higher continuous risk factors and with odds of being in a higher hypertension (OR: 1.77, 95%CI: 1.10–2.84) or diabetes (OR: 1.81, 95%CI: 1.06–3.10) category. A two‐fold increased VAT ratio was only associated with higher log‐insulin and log‐HOMA‐IR (β = 0.10, p < 0.05 for both), while a two‐fold increased thigh muscle:bone ratio was associated with a lower diabetes category (OR: 0.37, 95%CI: 0.14–1.01). CONCLUSIONS: These findings support ASAT as a significant driver of cardiometabolic disease in African Ancestry populations, independent of other abdominal and thigh tissues.
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spelling pubmed-86339262021-12-06 Relative associations of abdominal and thigh compositions with cardiometabolic diseases in African Caribbean men Tilves, Curtis Zmuda, Joseph M. Kuipers, Allison L. Nair, Sangeeta Carr, John Jeffrey Terry, James G. Peddada, Shyamal Wheeler, Victor Miljkovic, Iva Obes Sci Pract Original Articles BACKGROUND: Regional body compositions are differentially associated with cardiometabolic risk factors. Simultaneous inclusion of both upper and lower body composition predictors in models is not often done, and studies which do include both measures (1) tend to exclude some tissue(s) of potential metabolic relevance, and (2) have used study populations with underrepresentation of individuals with African ancestries. Further, most body composition analyses do not employ compositional data analytic approaches, which may result in spurious associations. OBJECTIVE: The objective of this analysis was to assess associations of abdominal and thigh adipose (AT) and muscle tissues with hypertension and type 2 diabetes using compositional data analytic methods. RESEARCH DESIGN AND METHODS: This cross‐sectional analysis included 610 African Caribbean men (median age: 62 years; mean BMI: 27.8 kg/m(2)). Abdominal (three components: subcutaneous [ASAT] and visceral [VAT] AT, ‘other’ abdominal tissue) and mid‐thigh (four components: subcutaneous and intermuscular AT, muscle, bone) compositions were measured by computed tomography; additive log ratio transformations were applied to each composition. Regression models were used to simultaneously assess associations of abdominal and thigh component ratios with continuous risk factors (blood pressures, fasting glucose and insulin, HOMA‐IR) and disease categories. RESULTS: A two‐fold increase in ASAT:‘Other’ ratio was associated with higher continuous risk factors and with odds of being in a higher hypertension (OR: 1.77, 95%CI: 1.10–2.84) or diabetes (OR: 1.81, 95%CI: 1.06–3.10) category. A two‐fold increased VAT ratio was only associated with higher log‐insulin and log‐HOMA‐IR (β = 0.10, p < 0.05 for both), while a two‐fold increased thigh muscle:bone ratio was associated with a lower diabetes category (OR: 0.37, 95%CI: 0.14–1.01). CONCLUSIONS: These findings support ASAT as a significant driver of cardiometabolic disease in African Ancestry populations, independent of other abdominal and thigh tissues. John Wiley and Sons Inc. 2021-05-21 /pmc/articles/PMC8633926/ /pubmed/34877013 http://dx.doi.org/10.1002/osp4.529 Text en © 2021 The Authors. Obesity Science & Practice published by World Obesity and The Obesity Society and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Tilves, Curtis
Zmuda, Joseph M.
Kuipers, Allison L.
Nair, Sangeeta
Carr, John Jeffrey
Terry, James G.
Peddada, Shyamal
Wheeler, Victor
Miljkovic, Iva
Relative associations of abdominal and thigh compositions with cardiometabolic diseases in African Caribbean men
title Relative associations of abdominal and thigh compositions with cardiometabolic diseases in African Caribbean men
title_full Relative associations of abdominal and thigh compositions with cardiometabolic diseases in African Caribbean men
title_fullStr Relative associations of abdominal and thigh compositions with cardiometabolic diseases in African Caribbean men
title_full_unstemmed Relative associations of abdominal and thigh compositions with cardiometabolic diseases in African Caribbean men
title_short Relative associations of abdominal and thigh compositions with cardiometabolic diseases in African Caribbean men
title_sort relative associations of abdominal and thigh compositions with cardiometabolic diseases in african caribbean men
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633926/
https://www.ncbi.nlm.nih.gov/pubmed/34877013
http://dx.doi.org/10.1002/osp4.529
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