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Traditional and novel cardiometabolic risk markers across strata of body mass index in young adults

BACKGROUND: Cardiometabolic risk increases with increasing body mass index (BMI). The exact mechanism is poorly understood, and traditional risk assessment of young adults with obesity has shown to be ineffective. Greater knowledge about potential new effective biomarkers and the use of advanced car...

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Autores principales: Kempel, Mia Klinkvort, Winding, Trine Nøhr, Lynggaard, Vibeke, Brantlov, Steven, Andersen, Johan Hviid, Böttcher, Morten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633932/
https://www.ncbi.nlm.nih.gov/pubmed/34877012
http://dx.doi.org/10.1002/osp4.528
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author Kempel, Mia Klinkvort
Winding, Trine Nøhr
Lynggaard, Vibeke
Brantlov, Steven
Andersen, Johan Hviid
Böttcher, Morten
author_facet Kempel, Mia Klinkvort
Winding, Trine Nøhr
Lynggaard, Vibeke
Brantlov, Steven
Andersen, Johan Hviid
Böttcher, Morten
author_sort Kempel, Mia Klinkvort
collection PubMed
description BACKGROUND: Cardiometabolic risk increases with increasing body mass index (BMI). The exact mechanism is poorly understood, and traditional risk assessment of young adults with obesity has shown to be ineffective. Greater knowledge about potential new effective biomarkers and the use of advanced cardiac imaging for risk assessment in young adults is, therefore, necessary. OBJECTIVE: This study aims to explore traditional and novel cardiometabolic risk markers across strata of BMI in young adults. METHODS: Participants (N = 264, 50% women, age 28–30 years) were invited from an ongoing cohort study, based on BMI and sex. BMI‐strata were: BMI <25, 25–30, >30 kg/m(2), representing normal weight (NW), overweight (OW), and obesity (OB). Participants underwent cardiac computed tomography to detect coronary artery calcification, measures of body composition, blood pressure measurements, and a comprehensive panel of circulating cardiometabolic risk markers. RESULTS: No significant coronary artery calcifications were detected in this study. Minor differences in median levels of traditional risk markers were detected across BMI‐strata, for example, total cholesterol (men‐ NW: 4.7 (4.3–5.1) and OB: 4.8 (4.2–5.6) mmol/L, p = 0.58; women‐ NW: 4.3 (3.9–4.8) and OB: 4.7 (4.2–5.3) mmol/L, p = 0.016), whereas substantial differences were seen in markers of inflammation and glucose metabolism, for example, high sensitive CRP (men‐ NW: 0.6 (0.3–1.1) and OB: 2.8 (1.5–4.0) mg/L, p < 0.001; women‐ NW: 0.7 (0.3–1.7) and OB: 4.0 (2.2–7.8) mg/L, p < 0.001) and insulin (men‐ NW: 47.0 (35.0–59.0) and OB: 113.5 (72.0–151.0) pmol/L, p < 0.001; women‐ NW: 44.0 (35.0–60.0) and OB: 84.5 (60.0–126.0) pmol/L, p < 0.001). CONCLUSION: In young adults, obesity is associated with an early onset insulin resistance and inflammatory response prior to development of coronary artery calcification and deterioration of lipid profiles.
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spelling pubmed-86339322021-12-06 Traditional and novel cardiometabolic risk markers across strata of body mass index in young adults Kempel, Mia Klinkvort Winding, Trine Nøhr Lynggaard, Vibeke Brantlov, Steven Andersen, Johan Hviid Böttcher, Morten Obes Sci Pract Original Articles BACKGROUND: Cardiometabolic risk increases with increasing body mass index (BMI). The exact mechanism is poorly understood, and traditional risk assessment of young adults with obesity has shown to be ineffective. Greater knowledge about potential new effective biomarkers and the use of advanced cardiac imaging for risk assessment in young adults is, therefore, necessary. OBJECTIVE: This study aims to explore traditional and novel cardiometabolic risk markers across strata of BMI in young adults. METHODS: Participants (N = 264, 50% women, age 28–30 years) were invited from an ongoing cohort study, based on BMI and sex. BMI‐strata were: BMI <25, 25–30, >30 kg/m(2), representing normal weight (NW), overweight (OW), and obesity (OB). Participants underwent cardiac computed tomography to detect coronary artery calcification, measures of body composition, blood pressure measurements, and a comprehensive panel of circulating cardiometabolic risk markers. RESULTS: No significant coronary artery calcifications were detected in this study. Minor differences in median levels of traditional risk markers were detected across BMI‐strata, for example, total cholesterol (men‐ NW: 4.7 (4.3–5.1) and OB: 4.8 (4.2–5.6) mmol/L, p = 0.58; women‐ NW: 4.3 (3.9–4.8) and OB: 4.7 (4.2–5.3) mmol/L, p = 0.016), whereas substantial differences were seen in markers of inflammation and glucose metabolism, for example, high sensitive CRP (men‐ NW: 0.6 (0.3–1.1) and OB: 2.8 (1.5–4.0) mg/L, p < 0.001; women‐ NW: 0.7 (0.3–1.7) and OB: 4.0 (2.2–7.8) mg/L, p < 0.001) and insulin (men‐ NW: 47.0 (35.0–59.0) and OB: 113.5 (72.0–151.0) pmol/L, p < 0.001; women‐ NW: 44.0 (35.0–60.0) and OB: 84.5 (60.0–126.0) pmol/L, p < 0.001). CONCLUSION: In young adults, obesity is associated with an early onset insulin resistance and inflammatory response prior to development of coronary artery calcification and deterioration of lipid profiles. John Wiley and Sons Inc. 2021-06-01 /pmc/articles/PMC8633932/ /pubmed/34877012 http://dx.doi.org/10.1002/osp4.528 Text en © 2021 The Authors. Obesity Science & Practice published by World Obesity and The Obesity Society and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Kempel, Mia Klinkvort
Winding, Trine Nøhr
Lynggaard, Vibeke
Brantlov, Steven
Andersen, Johan Hviid
Böttcher, Morten
Traditional and novel cardiometabolic risk markers across strata of body mass index in young adults
title Traditional and novel cardiometabolic risk markers across strata of body mass index in young adults
title_full Traditional and novel cardiometabolic risk markers across strata of body mass index in young adults
title_fullStr Traditional and novel cardiometabolic risk markers across strata of body mass index in young adults
title_full_unstemmed Traditional and novel cardiometabolic risk markers across strata of body mass index in young adults
title_short Traditional and novel cardiometabolic risk markers across strata of body mass index in young adults
title_sort traditional and novel cardiometabolic risk markers across strata of body mass index in young adults
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633932/
https://www.ncbi.nlm.nih.gov/pubmed/34877012
http://dx.doi.org/10.1002/osp4.528
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