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Sphingolipidomics of serum in extremely preterm infants: Association between low sphingosine-1-phosphate levels and severe retinopathy of prematurity

BACKGROUND: Extremely preterm infants are at risk of developing retinopathy of prematurity (ROP) that can cause impaired vision or blindness. Changes in blood lipids have been associated with ROP. This study aimed to monitor longitudinal changes in the serum sphingolipidome of extremely preterm infa...

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Autores principales: Nilsson, Anders K., Andersson, Mats X., Sjöbom, Ulrika, Hellgren, Gunnel, Lundgren, Pia, Pivodic, Aldina, Smith, Lois E.H., Hellström, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633973/
https://www.ncbi.nlm.nih.gov/pubmed/33862236
http://dx.doi.org/10.1016/j.bbalip.2021.158939
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author Nilsson, Anders K.
Andersson, Mats X.
Sjöbom, Ulrika
Hellgren, Gunnel
Lundgren, Pia
Pivodic, Aldina
Smith, Lois E.H.
Hellström, Ann
author_facet Nilsson, Anders K.
Andersson, Mats X.
Sjöbom, Ulrika
Hellgren, Gunnel
Lundgren, Pia
Pivodic, Aldina
Smith, Lois E.H.
Hellström, Ann
author_sort Nilsson, Anders K.
collection PubMed
description BACKGROUND: Extremely preterm infants are at risk of developing retinopathy of prematurity (ROP) that can cause impaired vision or blindness. Changes in blood lipids have been associated with ROP. This study aimed to monitor longitudinal changes in the serum sphingolipidome of extremely preterm infants and investigate the relationship to development of severe ROP. METHODS: This is a prospective study that included 47 infants born <28 gestational weeks. Serum samples were collected from cord blood and at postnatal days 1, 7, 14, and 28, and at postmenstrual weeks (PMW) 32, 36, and 40. Serum sphingolipids and phosphatidylcholines were extracted and analyzed by LC-MS/MS. Associations between sphingolipid species and ROP were assessed using mixed models for repeated measures. RESULTS: The serum concentration of all investigated lipid classes, including ceramide, mono- di- and trihexosylceramide, sphingomyelin, and phosphatidylcholine displayed distinct temporal patterns between birth and PMW40. There were also substantial changes in the lipid species composition within each class. Among the analyzed sphingolipid species, sphingosine-1-phosphate showed the strongest association with severe ROP, and this association was independent of gestational age at birth and weight standard deviation score change. CONCLUSIONS: The serum phospho- and sphingolipidome undergoes significant remodeling during the first weeks of the preterm infant’s life. Low postnatal levels of the signaling lipid sphingosine-1-phosphate are associated with the development of severe ROP.
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spelling pubmed-86339732021-12-01 Sphingolipidomics of serum in extremely preterm infants: Association between low sphingosine-1-phosphate levels and severe retinopathy of prematurity Nilsson, Anders K. Andersson, Mats X. Sjöbom, Ulrika Hellgren, Gunnel Lundgren, Pia Pivodic, Aldina Smith, Lois E.H. Hellström, Ann Biochim Biophys Acta Mol Cell Biol Lipids Article BACKGROUND: Extremely preterm infants are at risk of developing retinopathy of prematurity (ROP) that can cause impaired vision or blindness. Changes in blood lipids have been associated with ROP. This study aimed to monitor longitudinal changes in the serum sphingolipidome of extremely preterm infants and investigate the relationship to development of severe ROP. METHODS: This is a prospective study that included 47 infants born <28 gestational weeks. Serum samples were collected from cord blood and at postnatal days 1, 7, 14, and 28, and at postmenstrual weeks (PMW) 32, 36, and 40. Serum sphingolipids and phosphatidylcholines were extracted and analyzed by LC-MS/MS. Associations between sphingolipid species and ROP were assessed using mixed models for repeated measures. RESULTS: The serum concentration of all investigated lipid classes, including ceramide, mono- di- and trihexosylceramide, sphingomyelin, and phosphatidylcholine displayed distinct temporal patterns between birth and PMW40. There were also substantial changes in the lipid species composition within each class. Among the analyzed sphingolipid species, sphingosine-1-phosphate showed the strongest association with severe ROP, and this association was independent of gestational age at birth and weight standard deviation score change. CONCLUSIONS: The serum phospho- and sphingolipidome undergoes significant remodeling during the first weeks of the preterm infant’s life. Low postnatal levels of the signaling lipid sphingosine-1-phosphate are associated with the development of severe ROP. 2021-04-20 2021-07 /pmc/articles/PMC8633973/ /pubmed/33862236 http://dx.doi.org/10.1016/j.bbalip.2021.158939 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ).
spellingShingle Article
Nilsson, Anders K.
Andersson, Mats X.
Sjöbom, Ulrika
Hellgren, Gunnel
Lundgren, Pia
Pivodic, Aldina
Smith, Lois E.H.
Hellström, Ann
Sphingolipidomics of serum in extremely preterm infants: Association between low sphingosine-1-phosphate levels and severe retinopathy of prematurity
title Sphingolipidomics of serum in extremely preterm infants: Association between low sphingosine-1-phosphate levels and severe retinopathy of prematurity
title_full Sphingolipidomics of serum in extremely preterm infants: Association between low sphingosine-1-phosphate levels and severe retinopathy of prematurity
title_fullStr Sphingolipidomics of serum in extremely preterm infants: Association between low sphingosine-1-phosphate levels and severe retinopathy of prematurity
title_full_unstemmed Sphingolipidomics of serum in extremely preterm infants: Association between low sphingosine-1-phosphate levels and severe retinopathy of prematurity
title_short Sphingolipidomics of serum in extremely preterm infants: Association between low sphingosine-1-phosphate levels and severe retinopathy of prematurity
title_sort sphingolipidomics of serum in extremely preterm infants: association between low sphingosine-1-phosphate levels and severe retinopathy of prematurity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633973/
https://www.ncbi.nlm.nih.gov/pubmed/33862236
http://dx.doi.org/10.1016/j.bbalip.2021.158939
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