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Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases

Upregulation and stabilization of Foxp3 expression in Tregs are essential for regulating Treg function and immune homeostasis. In this study, gp96 immunization showed obvious therapeutic effects in a Lyn(–/–) mouse model of systemic lupus erythematosus. Moreover, gp96 alleviated the initiation and p...

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Detalles Bibliográficos
Autores principales:	Xu, Yuxiu, Liu, Erlong, Xie, Xialin, Wang, Jiuru, Zheng, Huaguo, Ju, Ying, Chen, Lizhao, Li, Changfei, Zhou, Xuyu, Li, Zihai, Li, Xin, Meng, Songdong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633978/ https://www.ncbi.nlm.nih.gov/pubmed/34877502 http://dx.doi.org/10.1016/j.isci.2021.103445

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