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GTP binding to translation factor eIF2B stimulates its guanine nucleotide exchange activity

eIF2B is the guanine nucleotide exchange factor (GEF) required for cytoplasmic protein synthesis initiation in eukaryotes and its regulation within the integrated stress response (ISR). It activates its partner factor eIF2, thereby promoting translation initiation. Here we provide evidence through b...

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Detalles Bibliográficos
Autores principales:	Kershaw, Christopher J., Jennings, Martin D., Cortopassi, Francesco, Guaita, Margherita, Al-Ghafli, Hawra, Pavitt, Graham D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633983/ https://www.ncbi.nlm.nih.gov/pubmed/34877508 http://dx.doi.org/10.1016/j.isci.2021.103454

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