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Dihydroceramide desaturase promotes the formation of intraluminal vesicles and inhibits autophagy to increase exosome production

Exosomes are important for cell–cell communication. Deficiencies in the human dihydroceramide desaturase gene, DEGS1, increase the dihydroceramide-to-ceramide ratio and cause hypomyelinating leukodystrophy. However, the disease mechanism remains unknown. Here, we developed an in vivo assay with spat...

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Detalles Bibliográficos
Autores principales:	Wu, Chen-Yi, Jhang, Jhih-Gang, Lin, Wan-Syuan, Chuang, Pei-Huan, Lin, Chih-Wei, Chu, Li-An, Chiang, Ann-Shyn, Ho, Han-Chen, Chan, Chih-Chiang, Huang, Shu-Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8633988/ https://www.ncbi.nlm.nih.gov/pubmed/34877496 http://dx.doi.org/10.1016/j.isci.2021.103437

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