Histone deacetylase 5 deacetylates the phosphatase PP2A for positively regulating NF-κB signaling

Histone deacetylase 5 (HDAC5) has been reported to have a strong regulatory function in the proinflammatory response, but the mechanism is still unknown. Here, we identified HDAC5 as a positive regulator of NF-κB signaling in vivo. HDAC5-deficient mice exhibited enhanced survival in response to LPS...

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Detalles Bibliográficos
Autores principales: Xu, Chonghui, Tang, Jielin, Yang, Qi, Zhao, He, Liu, Yaling, Cao, Juan, Zhou, Yuan, Chen, Xinwen, Chen, Jizheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634046/
https://www.ncbi.nlm.nih.gov/pubmed/34740611
http://dx.doi.org/10.1016/j.jbc.2021.101380

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