Glutamate Carboxypeptidase II in Aging Rat Prefrontal Cortex Impairs Working Memory Performance

Glutamate carboxypeptidase II (GCPII) expression in brain is increased by inflammation, and reduces NAAG (N-acetyl aspartyl glutamate) stimulation of mGluR3 signaling. Genetic insults in this signaling cascade are increasingly linked to cognitive disorders in humans, where increased GCPII and or dec...

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Detalles Bibliográficos
Autores principales: Datta, Dibyadeep, Leslie, Shannon N., Woo, Elizabeth, Amancharla, Nishita, Elmansy, Ayah, Lepe, Miguel, Mecca, Adam P., Slusher, Barbara S., Nairn, Angus C., Arnsten, Amy F. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634091/
https://www.ncbi.nlm.nih.gov/pubmed/34867287
http://dx.doi.org/10.3389/fnagi.2021.760270

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634091/
https://www.ncbi.nlm.nih.gov/pubmed/34867287
http://dx.doi.org/10.3389/fnagi.2021.760270

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