Effects of Diminished NADPH:cytochrome P450 Reductase in Human Hepatocytes on Lipid and Bile Acid Homeostasis

NADPH:cytochrome P450 oxidoreductase (POR) is the obligate electron donor for microsomal cytochrome P450 (CYP) enzymes involved in the biosynthesis of endogenous substances like bile acids and other steroids as well as in the oxidative metabolism of xenobiotics. P450 oxidoreductase also supports oth...

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Detalles Bibliográficos
Autores principales: Heintze, Tamara, Wilhelm, Denise, Schmidlin, Thierry, Hofmann, Ute, Zanger, Ulrich M., Schwab, Matthias, Klein, Kathrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634102/
https://www.ncbi.nlm.nih.gov/pubmed/34867397
http://dx.doi.org/10.3389/fphar.2021.769703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634102/
https://www.ncbi.nlm.nih.gov/pubmed/34867397
http://dx.doi.org/10.3389/fphar.2021.769703

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