Cargando…

Effects of Diminished NADPH:cytochrome P450 Reductase in Human Hepatocytes on Lipid and Bile Acid Homeostasis

NADPH:cytochrome P450 oxidoreductase (POR) is the obligate electron donor for microsomal cytochrome P450 (CYP) enzymes involved in the biosynthesis of endogenous substances like bile acids and other steroids as well as in the oxidative metabolism of xenobiotics. P450 oxidoreductase also supports oth...

Descripción completa

Detalles Bibliográficos
Autores principales:	Heintze, Tamara, Wilhelm, Denise, Schmidlin, Thierry, Hofmann, Ute, Zanger, Ulrich M., Schwab, Matthias, Klein, Kathrin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634102/ https://www.ncbi.nlm.nih.gov/pubmed/34867397 http://dx.doi.org/10.3389/fphar.2021.769703

Ejemplares similares

Differential effects on human cytochromes P450 by CRISPR/Cas9-induced genetic knockout of cytochrome P450 reductase and cytochrome b5 in HepaRG cells
por: Heintze, Tamara, et al.
Publicado: (2021)

Overexpression of human NADPH:cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069.
por: Patterson, A. V., et al.
Publicado: (1997)

NADPH:cytochrome c (P450) reductase activates tirapazamine (SR4233) to restore hypoxic and oxic cytotoxicity in an aerobic resistant derivative of the A549 lung cancer cell line
por: Saunders, M P, et al.
Publicado: (2000)

Allosteric modulation of cytochrome P450 enzymes by the NADPH cytochrome P450 reductase FMN-containing domain
por: Burris-Hiday, Sarah D., et al.
Publicado: (2023)

Nitroreduction of flutamide by Cunninghamella elegans NADPH: Cytochrome P450 reductase
por: Khan, Mohd Faheem, et al.
Publicado: (2022)

Contribution of NADPH-cytochrome P450 Reductase to Azole Resistance in Fusarium oxysporum
por: He, Dan, et al.
Publicado: (2021)

Cloning and Functional Characterization of NADPH-Cytochrome P450 Reductases in Aconitum vilmorinianum
por: Cheng, Jingping, et al.
Publicado: (2023)

Molecular Cloning and Identification of NADPH Cytochrome P450 Reductase from Panax ginseng
por: Zou, Xian, et al.
Publicado: (2021)

The Flavin-Containing Reductase Domain of Cytochrome P450 BM3 Acts as a Surrogate for Mammalian NADPH-P450 Reductase
por: Park, Seon-Ha, et al.
Publicado: (2012)

NADPH–Cytochrome P450 Reductase Mediates the Resistance of Aphis (Toxoptera) citricidus (Kirkaldy) to Abamectin
por: Jing, Tian-Xing, et al.
Publicado: (2018)

Genomic and Bioinformatic Analysis of NADPH-Cytochrome P450 Reductase in Anopheles stephensi (Diptera: Culicidae)
por: Suwanchaichinda, C., et al.
Publicado: (2014)

NADPH-cytochrome P450 reductase expression and enzymatic activity in primary-like human hepatocytes and HepG2 cells for in vitro biotransformation studies
por: Schulz, Christian, et al.
Publicado: (2019)

Silencing NADPH-cytochrome P450 reductase results in reduced acaricide resistance in Tetranychus cinnabarinus (Boisduval)
por: Shi, Li, et al.
Publicado: (2015)

Presence of nadph-cytochrome P-450 reductase in rat liver golgi membranes: Evidence obtained by immunoadsorption method
por: Ito, A, et al.
Publicado: (1978)

Functional characterization of NADPH-cytochrome P450 reductase from Bactrocera dorsalis: Possible involvement in susceptibility to malathion
por: Huang, Yong, et al.
Publicado: (2015)

The Hinge Segment of Human NADPH-Cytochrome P450 Reductase in Conformational Switching: The Critical Role of Ionic Strength
por: Campelo, Diana, et al.
Publicado: (2017)

Evaluation of RNA-knockdown strategies for modulation of cytochrome P450 reductase activity in mouse hepatocytes
por: Mackenzie, Neil CW, et al.
Publicado: (2010)

RNA Interference of NADPH-Cytochrome P450 Reductase Results in Reduced Insecticide Resistance in the Bed Bug, Cimex lectularius
por: Zhu, Fang, et al.
Publicado: (2012)

Correction: The Hinge Segment of Human NADPH-Cytochrome P450 Reductase in Conformational Switching: The Critical Role of Ionic Strength
por: Campelo, Diana, et al.
Publicado: (2018)

Evidence of Direct Generation of Oxygen Free Radicals from Heterocyclic Amines by NADPH/Cytochrome P‐450 Reductase in vitro
por: Sato, Keizo, et al.
Publicado: (1992)

Haplotype Diversity of NADPH-Cytochrome P450 Reductase Gene of Ophiocordyceps sinensis and the Effect on Fungal Infection in Host Insects
por: Xu, Zixian, et al.
Publicado: (2020)

Comparative Analysis of NADPH-Cytochrome P450 Reductases From Legumes for Heterologous Production of Triterpenoids in Transgenic Saccharomyces cerevisiae
por: Istiandari, Pramesti, et al.
Publicado: (2021)

A Novel, Highly Potent NADPH-Dependent Cytochrome P450 Reductase from Waste Liza klunzingeri Liver
por: Bahramian Nasab, Soudeh, et al.
Publicado: (2023)

Class I and II NADPH-cytochrome P450 reductases exhibit different roles in triterpenoid biosynthesis in Lotus japonicus
por: Istiandari, Pramesti, et al.
Publicado: (2023)

Cytochrome P-450 and NADPH-cytochrome P-450 reductase are degraded in the autolysosomes in rat liver [published erratum appears in J Cell Biol 1987 Jul;105(1):609]
Publicado: (1987)

Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the “Missing Heritability” Problem
por: Klein, Kathrin, et al.
Publicado: (2013)

Optimization of the process parameters for reduction of gossypol levels in cottonseed meal by functional recombinant NADPH-cytochrome P450 reductase and cytochrome P450 CYP9A12 of Helicoverpa armigera
por: Chen, Cheng, et al.
Publicado: (2019)

NADPH-Cytochrome P450 Reductase: Molecular Cloning and Functional Characterization of Two Paralogs from Withania somnifera (L.) Dunal
por: Rana, Satiander, et al.
Publicado: (2013)

Tobacco Cutworm (Spodoptera Litura) Larvae Silenced in the NADPH-Cytochrome P450 Reductase Gene Show Increased Susceptibility to Phoxim
por: Ji, Hong-Yi, et al.
Publicado: (2019)

The FMN “140s Loop” of Cytochrome P450 Reductase Controls Electron Transfer to Cytochrome P450
por: Rwere, Freeborn, et al.
Publicado: (2021)

Conformational Landscape of Cytochrome P450 Reductase Interactions
por: Sellner, Manuel, et al.
Publicado: (2021)

Membrane Associated Progesterone Receptors: Promiscuous Proteins with Pleiotropic Functions – Focus on Interactions with Cytochromes P450
por: Ryu, Chang S., et al.
Publicado: (2017)

Molecular Cloning, Expression Pattern and Polymorphisms of NADPH-Cytochrome P450 Reductase in the Bird Cherry-Oat Aphid Rhopalosiphum padi (L.)
por: Wang, Kang, et al.
Publicado: (2016)

In vivo and in vitro studies on the roles of p38 mitogen-activated protein kinase and NADPH-cytochrome P450 reductase in Alzheimer's disease
por: Yao, Yunyi, et al.
Publicado: (2017)

Functional characterization of NADPH-cytochrome P450 reductase and cinnamic acid 4-hydroxylase encoding genes from Scoparia dulcis L.
por: Yamamura, Yoshimi, et al.
Publicado: (2020)

Esterase, Glutathione S-Transferase and NADPH-Cytochrome P450 Reductase Activity Evaluation in Cacopsylla pyri L. (Hemiptera: Psyllidae) Individual Adults
por: Bosch-Serra, Dolors, et al.
Publicado: (2021)

Conformational Rearrangements in the Redox Cycling of NADPH-Cytochrome P450 Reductase from Sorghum bicolor Explored with FRET and Pressure-Perturbation Spectroscopy
por: Zhang, Bixia, et al.
Publicado: (2022)

NADPH–Cytochrome P450 Reductase Mediates the Fatty Acid Desaturation of ω3 and ω6 Desaturases from Mortierella alpina
por: Wang, Mingxuan, et al.
Publicado: (2022)

Peroxisome proliferator-activated receptor alpha, PPARα, directly regulates transcription of cytochrome P450 CYP2C8
por: Thomas, Maria, et al.
Publicado: (2015)

Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevance
por: Zanger, Ulrich M., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_1m4o9ihal3q69rv517l5mcqqat