Insights Into the Biological Role of NEDD4L E3 Ubiquitin Ligase in Human Cancers

Neural precursor cell expressed developmentally downregulated 4-like (NEDD4L) is an E3 ubiquitin ligase that has been reported to participate in multiple cellular procedures by regulating of substrate ubiquitination and subsequent protein degradation. A great amount of evidence has demonstrated that...

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Autores principales: Xie, Shangdan, Xia, Lu, Song, Yizuo, Liu, Hejing, Wang, Zhi-wei, Zhu, Xueqiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634104/
https://www.ncbi.nlm.nih.gov/pubmed/34869021
http://dx.doi.org/10.3389/fonc.2021.774648
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author Xie, Shangdan
Xia, Lu
Song, Yizuo
Liu, Hejing
Wang, Zhi-wei
Zhu, Xueqiong
author_facet Xie, Shangdan
Xia, Lu
Song, Yizuo
Liu, Hejing
Wang, Zhi-wei
Zhu, Xueqiong
author_sort Xie, Shangdan
collection PubMed
description Neural precursor cell expressed developmentally downregulated 4-like (NEDD4L) is an E3 ubiquitin ligase that has been reported to participate in multiple cellular procedures by regulating of substrate ubiquitination and subsequent protein degradation. A great amount of evidence has demonstrated that NEDD4L mainly functions as a tumor suppressor in most cancer types, while it also acts as an oncogene in a few cancers. In this review, we summarize the potential role of NEDD4L in carcinogenesis and the related underlying molecular mechanism to improve our understanding of its functions in the tumorigenesis of human malignancies. Developing clinical drugs targeting NEDD4L could be a potential therapeutic strategy for cancer therapy in the future.
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spelling pubmed-86341042021-12-02 Insights Into the Biological Role of NEDD4L E3 Ubiquitin Ligase in Human Cancers Xie, Shangdan Xia, Lu Song, Yizuo Liu, Hejing Wang, Zhi-wei Zhu, Xueqiong Front Oncol Oncology Neural precursor cell expressed developmentally downregulated 4-like (NEDD4L) is an E3 ubiquitin ligase that has been reported to participate in multiple cellular procedures by regulating of substrate ubiquitination and subsequent protein degradation. A great amount of evidence has demonstrated that NEDD4L mainly functions as a tumor suppressor in most cancer types, while it also acts as an oncogene in a few cancers. In this review, we summarize the potential role of NEDD4L in carcinogenesis and the related underlying molecular mechanism to improve our understanding of its functions in the tumorigenesis of human malignancies. Developing clinical drugs targeting NEDD4L could be a potential therapeutic strategy for cancer therapy in the future. Frontiers Media S.A. 2021-11-15 /pmc/articles/PMC8634104/ /pubmed/34869021 http://dx.doi.org/10.3389/fonc.2021.774648 Text en Copyright © 2021 Xie, Xia, Song, Liu, Wang and Zhu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Xie, Shangdan
Xia, Lu
Song, Yizuo
Liu, Hejing
Wang, Zhi-wei
Zhu, Xueqiong
Insights Into the Biological Role of NEDD4L E3 Ubiquitin Ligase in Human Cancers
title Insights Into the Biological Role of NEDD4L E3 Ubiquitin Ligase in Human Cancers
title_full Insights Into the Biological Role of NEDD4L E3 Ubiquitin Ligase in Human Cancers
title_fullStr Insights Into the Biological Role of NEDD4L E3 Ubiquitin Ligase in Human Cancers
title_full_unstemmed Insights Into the Biological Role of NEDD4L E3 Ubiquitin Ligase in Human Cancers
title_short Insights Into the Biological Role of NEDD4L E3 Ubiquitin Ligase in Human Cancers
title_sort insights into the biological role of nedd4l e3 ubiquitin ligase in human cancers
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634104/
https://www.ncbi.nlm.nih.gov/pubmed/34869021
http://dx.doi.org/10.3389/fonc.2021.774648
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