Cargando…
Pharmacological SARM1 inhibition protects axon structure and function in paclitaxel-induced peripheral neuropathy
Axonal degeneration is an early and ongoing event that causes disability and disease progression in many neurodegenerative disorders of the peripheral and central nervous systems. Chemotherapy-induced peripheral neuropathy (CIPN) is a major cause of morbidity and the main cause of dose reductions an...
Autores principales: | Bosanac, Todd, Hughes, Robert O, Engber, Thomas, Devraj, Rajesh, Brearley, Andrew, Danker, Kerstin, Young, Kenneth, Kopatz, Jens, Hermann, Melanie, Berthemy, Antoine, Boyce, Susan, Bentley, Jonathan, Krauss, Raul |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634121/ https://www.ncbi.nlm.nih.gov/pubmed/33964142 http://dx.doi.org/10.1093/brain/awab184 |
Ejemplares similares
-
Small Molecule SARM1 Inhibitors Recapitulate the SARM1(−/−) Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate
por: Hughes, Robert O., et al.
Publicado: (2021) -
Multifaceted roles of SARM1 in axon degeneration and signaling
por: Waller, Thomas J., et al.
Publicado: (2022) -
SARM1 Suppresses Axon Branching Through Attenuation of Axonal Cytoskeletal Dynamics
por: Ketschek, Andrea, et al.
Publicado: (2022) -
TIR-1/SARM1 inhibits axon regeneration and promotes axon degeneration
por: Czech, Victoria L, et al.
Publicado: (2023) -
Macrophage depletion blocks congenital SARM1-dependent neuropathy
por: Dingwall, Caitlin B., et al.
Publicado: (2022)