The nucleoporin Nup50 activates the Ran guanine nucleotide exchange factor RCC1 to promote NPC assembly at the end of mitosis

During mitotic exit, thousands of nuclear pore complexes (NPCs) assemble concomitant with the nuclear envelope to build a transport‐competent nucleus. Here, we show that Nup50 plays a crucial role in NPC assembly independent of its well‐established function in nuclear transport. RNAi‐mediated downre...

Descripción completa

Detalles Bibliográficos
Autores principales: Holzer, Guillaume, De Magistris, Paola, Gramminger, Cathrin, Sachdev, Ruchika, Magalska, Adriana, Schooley, Allana, Scheufen, Anja, Lennartz, Birgitt, Tatarek‐Nossol, Marianna, Lue, Hongqi, Linder, Monika I, Kutay, Ulrike, Preisinger, Christian, Moreno‐Andres, Daniel, Antonin, Wolfram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634129/
https://www.ncbi.nlm.nih.gov/pubmed/34725842
http://dx.doi.org/10.15252/embj.2021108788

Ejemplares similares

Ejemplares similares