Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations

Genomic studies of pediatric acute lymphoblastic leukemia (ALL) have shown remarkable heterogeneity in initial diagnosis, with multiple (sub)clones harboring lesions in relapse-associated genes. However, the clinical relevance of these subclonal alterations remains unclear. We assessed the clinical...

Descripción completa

Detalles Bibliográficos
Autores principales: Antić, Željko, Yu, Jiangyan, van Reijmersdal, Simon V., van Dijk, Anke, Dekker, Linde, Segerink, Wouter H., Sonneveld, Edwin, Fiocco, Marta, Pieters, Rob, Hoogerbrugge, Peter M., van Leeuwen, Frank N., van Kessel, Ad Geurts, Waanders, Esmé, Kuiper, Roland P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634184/
https://www.ncbi.nlm.nih.gov/pubmed/33147938
http://dx.doi.org/10.3324/haematol.2020.259226

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634184/
https://www.ncbi.nlm.nih.gov/pubmed/33147938
http://dx.doi.org/10.3324/haematol.2020.259226

Ejemplares similares