The IL1-IL1RAP axis plays an important role in the inflammatory leukemic niche that favors acute myeloid leukemia proliferation over normal hematopoiesis

Upregulation of the plasma membrane receptor IL1RAP in acute myeloid leukemia (AML) has been reported but its role in the context of the leukemic bone marrow niche is unclear. Here, we studied the signaling events downstream of IL1RAP in relation to leukemogenesis and normal hematopoiesis. High IL1R...

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Detalles Bibliográficos
Autores principales: de Boer, Bauke, Sheveleva, Sofia, Apelt, Katja, Vellenga, Edo, Mulder, André B., Huls, Gerwin, Schuringa, Jan Jacob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634188/
https://www.ncbi.nlm.nih.gov/pubmed/33121233
http://dx.doi.org/10.3324/haematol.2020.254987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634188/
https://www.ncbi.nlm.nih.gov/pubmed/33121233
http://dx.doi.org/10.3324/haematol.2020.254987

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