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Protein- and Calcium-Mediated GLP-1 Secretion: A Narrative Review
Glucagon-like peptide 1 (GLP-1) is an incretin hormone produced in the intestine that is secreted in response to nutrient exposure. GLP-1 potentiates glucose-dependent insulin secretion from the pancreatic β cells and promotes satiety. These important actions on glucose metabolism and appetite have...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634310/ https://www.ncbi.nlm.nih.gov/pubmed/34192748 http://dx.doi.org/10.1093/advances/nmab078 |
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author | Watkins, Jonathan D Koumanov, Françoise Gonzalez, Javier T |
author_facet | Watkins, Jonathan D Koumanov, Françoise Gonzalez, Javier T |
author_sort | Watkins, Jonathan D |
collection | PubMed |
description | Glucagon-like peptide 1 (GLP-1) is an incretin hormone produced in the intestine that is secreted in response to nutrient exposure. GLP-1 potentiates glucose-dependent insulin secretion from the pancreatic β cells and promotes satiety. These important actions on glucose metabolism and appetite have led to widespread interest in GLP-1 receptor agonism. Typically, this involves pharmacological GLP-1 mimetics or targeted inhibition of dipeptidyl peptidase-IV, the enzyme responsible for GLP-1 degradation. However, nutritional strategies provide a widely available, cost-effective alternative to pharmacological strategies for enhancing hormone release. Recent advances in nutritional research have implicated the combined ingestion of protein and calcium with enhanced endogenous GLP-1 release, which is likely due to activation of receptors with high affinity and/or sensitivity for amino acids and calcium. Specifically targeting these receptors could enhance gut hormone secretion, thus providing a new therapeutic option. This narrative review provides an overview of the latest research on protein- and calcium-mediated GLP-1 release with an emphasis on human data, and a perspective on potential mechanisms that link potent GLP-1 release to the co-ingestion of protein and calcium. In light of these recent findings, potential future research directions are also presented. |
format | Online Article Text |
id | pubmed-8634310 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-86343102021-12-01 Protein- and Calcium-Mediated GLP-1 Secretion: A Narrative Review Watkins, Jonathan D Koumanov, Françoise Gonzalez, Javier T Adv Nutr Review Glucagon-like peptide 1 (GLP-1) is an incretin hormone produced in the intestine that is secreted in response to nutrient exposure. GLP-1 potentiates glucose-dependent insulin secretion from the pancreatic β cells and promotes satiety. These important actions on glucose metabolism and appetite have led to widespread interest in GLP-1 receptor agonism. Typically, this involves pharmacological GLP-1 mimetics or targeted inhibition of dipeptidyl peptidase-IV, the enzyme responsible for GLP-1 degradation. However, nutritional strategies provide a widely available, cost-effective alternative to pharmacological strategies for enhancing hormone release. Recent advances in nutritional research have implicated the combined ingestion of protein and calcium with enhanced endogenous GLP-1 release, which is likely due to activation of receptors with high affinity and/or sensitivity for amino acids and calcium. Specifically targeting these receptors could enhance gut hormone secretion, thus providing a new therapeutic option. This narrative review provides an overview of the latest research on protein- and calcium-mediated GLP-1 release with an emphasis on human data, and a perspective on potential mechanisms that link potent GLP-1 release to the co-ingestion of protein and calcium. In light of these recent findings, potential future research directions are also presented. Oxford University Press 2021-06-30 /pmc/articles/PMC8634310/ /pubmed/34192748 http://dx.doi.org/10.1093/advances/nmab078 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Watkins, Jonathan D Koumanov, Françoise Gonzalez, Javier T Protein- and Calcium-Mediated GLP-1 Secretion: A Narrative Review |
title | Protein- and Calcium-Mediated GLP-1 Secretion: A Narrative Review |
title_full | Protein- and Calcium-Mediated GLP-1 Secretion: A Narrative Review |
title_fullStr | Protein- and Calcium-Mediated GLP-1 Secretion: A Narrative Review |
title_full_unstemmed | Protein- and Calcium-Mediated GLP-1 Secretion: A Narrative Review |
title_short | Protein- and Calcium-Mediated GLP-1 Secretion: A Narrative Review |
title_sort | protein- and calcium-mediated glp-1 secretion: a narrative review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634310/ https://www.ncbi.nlm.nih.gov/pubmed/34192748 http://dx.doi.org/10.1093/advances/nmab078 |
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