Serum IL-33 as a biomarker in different diseases: useful parameter or much need for clarification?

Interleukin-33 (IL-33), a member of the IL-1 family, is critically involved in the modulation of the activity of a diverse range of immunocompetent cells. Essential roles have been implicated in cardioprotection, in both innate and adaptive immune responses in mucosal organs, and in the maintenance...

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Autores principales: Erfurt, Stefan, Hoffmeister, Meike, Oess, Stefanie, Asmus, Katharina, Ritter, Oliver, Patschan, Susann, Patschan, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AboutScience 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634375/
https://www.ncbi.nlm.nih.gov/pubmed/34858526
http://dx.doi.org/10.33393/jcb.2021.2327
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author Erfurt, Stefan
Hoffmeister, Meike
Oess, Stefanie
Asmus, Katharina
Ritter, Oliver
Patschan, Susann
Patschan, Daniel
author_facet Erfurt, Stefan
Hoffmeister, Meike
Oess, Stefanie
Asmus, Katharina
Ritter, Oliver
Patschan, Susann
Patschan, Daniel
author_sort Erfurt, Stefan
collection PubMed
description Interleukin-33 (IL-33), a member of the IL-1 family, is critically involved in the modulation of the activity of a diverse range of immunocompetent cells. Essential roles have been implicated in cardioprotection, in both innate and adaptive immune responses in mucosal organs, and in the maintenance of adipose tissue cells. Over the past 10 years, several studies evaluated the usability of IL-33 as a biomarker in diseases of inflammatory and noninflammatory origin. Our group is currently evaluating the predictive role of serum IL-33 in acute kidney injury (AKI). The aim of the article is to discuss selected studies on IL-33 in different diseases and its potential role as a biomarker molecule.
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spelling pubmed-86343752021-12-01 Serum IL-33 as a biomarker in different diseases: useful parameter or much need for clarification? Erfurt, Stefan Hoffmeister, Meike Oess, Stefanie Asmus, Katharina Ritter, Oliver Patschan, Susann Patschan, Daniel J Circ Biomark Review Interleukin-33 (IL-33), a member of the IL-1 family, is critically involved in the modulation of the activity of a diverse range of immunocompetent cells. Essential roles have been implicated in cardioprotection, in both innate and adaptive immune responses in mucosal organs, and in the maintenance of adipose tissue cells. Over the past 10 years, several studies evaluated the usability of IL-33 as a biomarker in diseases of inflammatory and noninflammatory origin. Our group is currently evaluating the predictive role of serum IL-33 in acute kidney injury (AKI). The aim of the article is to discuss selected studies on IL-33 in different diseases and its potential role as a biomarker molecule. AboutScience 2021-11-30 /pmc/articles/PMC8634375/ /pubmed/34858526 http://dx.doi.org/10.33393/jcb.2021.2327 Text en Copyright © 2021, The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/Journal of Circulating Biomarkers - ISSN 1849-4544 - www.aboutscience.eu/jcb (http://www.aboutscience.eu/jcb) © 2021 The Authors. This article is published by AboutScience and licensed under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Commercial use is not permitted and is subject to Publisher’s permissions. Full information is available at www.aboutscience.eu (http://www.aboutscience.eu)
spellingShingle Review
Erfurt, Stefan
Hoffmeister, Meike
Oess, Stefanie
Asmus, Katharina
Ritter, Oliver
Patschan, Susann
Patschan, Daniel
Serum IL-33 as a biomarker in different diseases: useful parameter or much need for clarification?
title Serum IL-33 as a biomarker in different diseases: useful parameter or much need for clarification?
title_full Serum IL-33 as a biomarker in different diseases: useful parameter or much need for clarification?
title_fullStr Serum IL-33 as a biomarker in different diseases: useful parameter or much need for clarification?
title_full_unstemmed Serum IL-33 as a biomarker in different diseases: useful parameter or much need for clarification?
title_short Serum IL-33 as a biomarker in different diseases: useful parameter or much need for clarification?
title_sort serum il-33 as a biomarker in different diseases: useful parameter or much need for clarification?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634375/
https://www.ncbi.nlm.nih.gov/pubmed/34858526
http://dx.doi.org/10.33393/jcb.2021.2327
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