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Body composition of adults with a history of severe acute malnutrition during childhood using the deuterium dilution method in eastern DR Congo: the Lwiro Cohort Study

BACKGROUND: Few studies have evaluated the body composition (BC) of adults who suffered from severe acute malnutrition (SAM) during childhood, a population at risk of long-term noncommunicable diseases. OBJECTIVE: We performed an observational cohort study to evaluate BC in a group of young adults a...

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Autores principales: Mwene-Batu, Pacifique, Wells, Jonathan, Maheshe, Ghislain, Hermans, Michel P, Kalumuna, Esther, Ngaboyeka, Gaylord, Chimanuka, Christine, Owino, Victor O, Macq, Jean, Lukula, Melissa, Dramaix, Michelle, Donnen, Philippe, Bisimwa, Ghislain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634579/
https://www.ncbi.nlm.nih.gov/pubmed/34582550
http://dx.doi.org/10.1093/ajcn/nqab293
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author Mwene-Batu, Pacifique
Wells, Jonathan
Maheshe, Ghislain
Hermans, Michel P
Kalumuna, Esther
Ngaboyeka, Gaylord
Chimanuka, Christine
Owino, Victor O
Macq, Jean
Lukula, Melissa
Dramaix, Michelle
Donnen, Philippe
Bisimwa, Ghislain
author_facet Mwene-Batu, Pacifique
Wells, Jonathan
Maheshe, Ghislain
Hermans, Michel P
Kalumuna, Esther
Ngaboyeka, Gaylord
Chimanuka, Christine
Owino, Victor O
Macq, Jean
Lukula, Melissa
Dramaix, Michelle
Donnen, Philippe
Bisimwa, Ghislain
author_sort Mwene-Batu, Pacifique
collection PubMed
description BACKGROUND: Few studies have evaluated the body composition (BC) of adults who suffered from severe acute malnutrition (SAM) during childhood, a population at risk of long-term noncommunicable diseases. OBJECTIVE: We performed an observational cohort study to evaluate BC in a group of young adults aged 11–30 y after nutritional rehabilitation for SAM, in the Democratic Republic of the Congo (DRC). METHODS: We evaluated 151 adults in eastern DRC who were treated for SAM during childhood between 1988 and 2007. They were compared with 120 aged- and sex-matched control adults living in the same community who had not been exposed to malnutrition as children. The main variables of interest were the different compartments of adult BC (fat-free mass [FFM], fat mass [FM], and 2 indices of height-normalized BC: FFM index [FFMI] and FM index [FMI]) measured by deuterium dilution. RESULTS: The mean age in both groups was 23 y, and females represented 49% and 56% of the exposed and nonexposed groups, respectively. SAM-exposed males had lower mean ± SD weight (53.6 ± 6.4 compared with 56.4 ± 7.9 kg, P = 0.029) and lower height (159.9 ± 6.6 compared with 163.6 ± 6.7 cm, P = 0.003) compared to unexposed males. SAM-exposed subjects had less FFM (–1.56 kg [–2.93, –0.20]; P = 0.024) but this observation was more marked in males (45.4 ± 5.4 compared with 48.2 ± 6.9 kg, P = 0.01) than in females. No differences in FM were noted between SAM-exposed and unexposed subjects. Adjusting for height, FFMI and FMI showed no difference between SAM-exposed and unexposed in either sex. CONCLUSION: SAM during childhood is associated with reduced FFM in adulthood which is probably due to a shorter height.
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spelling pubmed-86345792021-12-02 Body composition of adults with a history of severe acute malnutrition during childhood using the deuterium dilution method in eastern DR Congo: the Lwiro Cohort Study Mwene-Batu, Pacifique Wells, Jonathan Maheshe, Ghislain Hermans, Michel P Kalumuna, Esther Ngaboyeka, Gaylord Chimanuka, Christine Owino, Victor O Macq, Jean Lukula, Melissa Dramaix, Michelle Donnen, Philippe Bisimwa, Ghislain Am J Clin Nutr Original Research Communications BACKGROUND: Few studies have evaluated the body composition (BC) of adults who suffered from severe acute malnutrition (SAM) during childhood, a population at risk of long-term noncommunicable diseases. OBJECTIVE: We performed an observational cohort study to evaluate BC in a group of young adults aged 11–30 y after nutritional rehabilitation for SAM, in the Democratic Republic of the Congo (DRC). METHODS: We evaluated 151 adults in eastern DRC who were treated for SAM during childhood between 1988 and 2007. They were compared with 120 aged- and sex-matched control adults living in the same community who had not been exposed to malnutrition as children. The main variables of interest were the different compartments of adult BC (fat-free mass [FFM], fat mass [FM], and 2 indices of height-normalized BC: FFM index [FFMI] and FM index [FMI]) measured by deuterium dilution. RESULTS: The mean age in both groups was 23 y, and females represented 49% and 56% of the exposed and nonexposed groups, respectively. SAM-exposed males had lower mean ± SD weight (53.6 ± 6.4 compared with 56.4 ± 7.9 kg, P = 0.029) and lower height (159.9 ± 6.6 compared with 163.6 ± 6.7 cm, P = 0.003) compared to unexposed males. SAM-exposed subjects had less FFM (–1.56 kg [–2.93, –0.20]; P = 0.024) but this observation was more marked in males (45.4 ± 5.4 compared with 48.2 ± 6.9 kg, P = 0.01) than in females. No differences in FM were noted between SAM-exposed and unexposed subjects. Adjusting for height, FFMI and FMI showed no difference between SAM-exposed and unexposed in either sex. CONCLUSION: SAM during childhood is associated with reduced FFM in adulthood which is probably due to a shorter height. Oxford University Press 2021-09-28 /pmc/articles/PMC8634579/ /pubmed/34582550 http://dx.doi.org/10.1093/ajcn/nqab293 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of the American Society for Nutrition. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Research Communications
Mwene-Batu, Pacifique
Wells, Jonathan
Maheshe, Ghislain
Hermans, Michel P
Kalumuna, Esther
Ngaboyeka, Gaylord
Chimanuka, Christine
Owino, Victor O
Macq, Jean
Lukula, Melissa
Dramaix, Michelle
Donnen, Philippe
Bisimwa, Ghislain
Body composition of adults with a history of severe acute malnutrition during childhood using the deuterium dilution method in eastern DR Congo: the Lwiro Cohort Study
title Body composition of adults with a history of severe acute malnutrition during childhood using the deuterium dilution method in eastern DR Congo: the Lwiro Cohort Study
title_full Body composition of adults with a history of severe acute malnutrition during childhood using the deuterium dilution method in eastern DR Congo: the Lwiro Cohort Study
title_fullStr Body composition of adults with a history of severe acute malnutrition during childhood using the deuterium dilution method in eastern DR Congo: the Lwiro Cohort Study
title_full_unstemmed Body composition of adults with a history of severe acute malnutrition during childhood using the deuterium dilution method in eastern DR Congo: the Lwiro Cohort Study
title_short Body composition of adults with a history of severe acute malnutrition during childhood using the deuterium dilution method in eastern DR Congo: the Lwiro Cohort Study
title_sort body composition of adults with a history of severe acute malnutrition during childhood using the deuterium dilution method in eastern dr congo: the lwiro cohort study
topic Original Research Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634579/
https://www.ncbi.nlm.nih.gov/pubmed/34582550
http://dx.doi.org/10.1093/ajcn/nqab293
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