Intrahippocampal Adeno-Associated Virus–Mediated Overexpression of Nerve Growth Factor Reverses 192IgG-Saporin–Induced Impairments of Hippocampal Plasticity and Behavior

One of the aspects of Alzheimer disease is loss of cholinergic neurons in the basal forebrain, which leads to development of cognitive impairment. Here, we used a model of cholinergic deficit caused by immunotoxin 192IgG-saporin to study possible beneficial effects of adeno-associated virus (AAV)–me...

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Detalles Bibliográficos
Autores principales: Dobryakova, Yulia V., Spivak, Yulia S., Zaichenko, Maria I., Koryagina, Alena A., Markevich, Vladimir A., Stepanichev, Mikhail Yu., Bolshakov, Alexey P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634591/
https://www.ncbi.nlm.nih.gov/pubmed/34867156
http://dx.doi.org/10.3389/fnins.2021.745050

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