XAV-19, a Swine Glyco-Humanized Polyclonal Antibody Against SARS-CoV-2 Spike Receptor-Binding Domain, Targets Multiple Epitopes and Broadly Neutralizes Variants

Amino acid substitutions and deletions in the Spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants can reduce the effectiveness of monoclonal antibodies (mAbs). In contrast, heterologous polyclonal antibodies raised against S protein, through the recognition of mult...

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Detalles Bibliográficos
Autores principales: Vanhove, Bernard, Marot, Stéphane, So, Ray T., Gaborit, Benjamin, Evanno, Gwénaëlle, Malet, Isabelle, Lafrogne, Guillaume, Mevel, Edwige, Ciron, Carine, Royer, Pierre-Joseph, Lheriteau, Elsa, Raffi, François, Bruzzone, Roberto, Mok, Chris Ka Pun, Duvaux, Odile, Marcelin, Anne-Geneviève, Calvez, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634597/
https://www.ncbi.nlm.nih.gov/pubmed/34868003
http://dx.doi.org/10.3389/fimmu.2021.761250

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