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Roles of Integrins in Gastrointestinal Cancer Metastasis
Integrins are a large family of heterodimeric transmembrane receptors which mediate cell adhesion and transmit signals to the cell interior. The mechanistic roles of integrins have long been an enigma in cancer, given its complexity in regulating different cellular behaviors. Recently, however, incr...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634653/ https://www.ncbi.nlm.nih.gov/pubmed/34869579 http://dx.doi.org/10.3389/fmolb.2021.708779 |
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author | Hou, Sicong Wang, Jiaxin Li, Wenqian Hao, Xin Hang, Qinglei |
author_facet | Hou, Sicong Wang, Jiaxin Li, Wenqian Hao, Xin Hang, Qinglei |
author_sort | Hou, Sicong |
collection | PubMed |
description | Integrins are a large family of heterodimeric transmembrane receptors which mediate cell adhesion and transmit signals to the cell interior. The mechanistic roles of integrins have long been an enigma in cancer, given its complexity in regulating different cellular behaviors. Recently, however, increasing research is providing new insights into its function and the underlying mechanisms, which collectively include the influences of altered integrin expression on the aberrant signaling pathways and cancer progression. Many studies have also demonstrated the potentiality of integrins as therapeutic targets in cancer treatment. In this review, we have summarized these recent reports and put a particular emphasis on the dysregulated expression of integrins and how they regulate related signaling pathways to facilitate the metastatic progression of gastrointestinal cancer, including gastric cancer (GC) and colorectal cancer (CRC), which will address the crucial roles of integrins in gastrointestinal cancer. |
format | Online Article Text |
id | pubmed-8634653 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86346532021-12-02 Roles of Integrins in Gastrointestinal Cancer Metastasis Hou, Sicong Wang, Jiaxin Li, Wenqian Hao, Xin Hang, Qinglei Front Mol Biosci Molecular Biosciences Integrins are a large family of heterodimeric transmembrane receptors which mediate cell adhesion and transmit signals to the cell interior. The mechanistic roles of integrins have long been an enigma in cancer, given its complexity in regulating different cellular behaviors. Recently, however, increasing research is providing new insights into its function and the underlying mechanisms, which collectively include the influences of altered integrin expression on the aberrant signaling pathways and cancer progression. Many studies have also demonstrated the potentiality of integrins as therapeutic targets in cancer treatment. In this review, we have summarized these recent reports and put a particular emphasis on the dysregulated expression of integrins and how they regulate related signaling pathways to facilitate the metastatic progression of gastrointestinal cancer, including gastric cancer (GC) and colorectal cancer (CRC), which will address the crucial roles of integrins in gastrointestinal cancer. Frontiers Media S.A. 2021-11-15 /pmc/articles/PMC8634653/ /pubmed/34869579 http://dx.doi.org/10.3389/fmolb.2021.708779 Text en Copyright © 2021 Hou, Wang, Li, Hao and Hang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Molecular Biosciences Hou, Sicong Wang, Jiaxin Li, Wenqian Hao, Xin Hang, Qinglei Roles of Integrins in Gastrointestinal Cancer Metastasis |
title | Roles of Integrins in Gastrointestinal Cancer Metastasis |
title_full | Roles of Integrins in Gastrointestinal Cancer Metastasis |
title_fullStr | Roles of Integrins in Gastrointestinal Cancer Metastasis |
title_full_unstemmed | Roles of Integrins in Gastrointestinal Cancer Metastasis |
title_short | Roles of Integrins in Gastrointestinal Cancer Metastasis |
title_sort | roles of integrins in gastrointestinal cancer metastasis |
topic | Molecular Biosciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634653/ https://www.ncbi.nlm.nih.gov/pubmed/34869579 http://dx.doi.org/10.3389/fmolb.2021.708779 |
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