Successful seroconversion following mild COVID-19 contraction in a double-vaccinated B-cell-depleted person with multiple sclerosis: A hint towards booster efficacy?

BACKGROUND: While early booster administration has been started in many regions to tackle failure of seroconversion among people with multiple sclerosis (pwMS) on anti-CD20 therapies (aCD20), its efficacy is still doubted in presence of B-cell depletion. CASE PRESENTATION: We report the case of a ri...

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Autores principales: Etemadifar, Masoud, Nouri, Hosein, Salari, Mehri, Sedaghat, Nahad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier B.V. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634689/
http://dx.doi.org/10.1016/j.nerep.2021.100047
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author Etemadifar, Masoud
Nouri, Hosein
Salari, Mehri
Sedaghat, Nahad
author_facet Etemadifar, Masoud
Nouri, Hosein
Salari, Mehri
Sedaghat, Nahad
author_sort Etemadifar, Masoud
collection PubMed
description BACKGROUND: While early booster administration has been started in many regions to tackle failure of seroconversion among people with multiple sclerosis (pwMS) on anti-CD20 therapies (aCD20), its efficacy is still doubted in presence of B-cell depletion. CASE PRESENTATION: We report the case of a rituximab-treated person with MS who contracted COVID-19 after being double-vaccinated. While hypothesizing that COVID-19 contraction itself could mimic a vaccination booster, we investigated anti-SARS-CoV-2-Spike serology and B-cell counts in this case. The results showed successful seroconversion despite low relative counts of CD19+ and CD20+ cells. CONCLUSION: Until further population-based data becomes available, further administration of early boosters among pwMS on aCD20 is highly encouraged.
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spelling pubmed-86346892021-12-01 Successful seroconversion following mild COVID-19 contraction in a double-vaccinated B-cell-depleted person with multiple sclerosis: A hint towards booster efficacy? Etemadifar, Masoud Nouri, Hosein Salari, Mehri Sedaghat, Nahad Neuroimmunology Reports Article BACKGROUND: While early booster administration has been started in many regions to tackle failure of seroconversion among people with multiple sclerosis (pwMS) on anti-CD20 therapies (aCD20), its efficacy is still doubted in presence of B-cell depletion. CASE PRESENTATION: We report the case of a rituximab-treated person with MS who contracted COVID-19 after being double-vaccinated. While hypothesizing that COVID-19 contraction itself could mimic a vaccination booster, we investigated anti-SARS-CoV-2-Spike serology and B-cell counts in this case. The results showed successful seroconversion despite low relative counts of CD19+ and CD20+ cells. CONCLUSION: Until further population-based data becomes available, further administration of early boosters among pwMS on aCD20 is highly encouraged. The Authors. Published by Elsevier B.V. 2021-12 2021-12-01 /pmc/articles/PMC8634689/ http://dx.doi.org/10.1016/j.nerep.2021.100047 Text en © 2021 The Authors. Published by Elsevier B.V. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Etemadifar, Masoud
Nouri, Hosein
Salari, Mehri
Sedaghat, Nahad
Successful seroconversion following mild COVID-19 contraction in a double-vaccinated B-cell-depleted person with multiple sclerosis: A hint towards booster efficacy?
title Successful seroconversion following mild COVID-19 contraction in a double-vaccinated B-cell-depleted person with multiple sclerosis: A hint towards booster efficacy?
title_full Successful seroconversion following mild COVID-19 contraction in a double-vaccinated B-cell-depleted person with multiple sclerosis: A hint towards booster efficacy?
title_fullStr Successful seroconversion following mild COVID-19 contraction in a double-vaccinated B-cell-depleted person with multiple sclerosis: A hint towards booster efficacy?
title_full_unstemmed Successful seroconversion following mild COVID-19 contraction in a double-vaccinated B-cell-depleted person with multiple sclerosis: A hint towards booster efficacy?
title_short Successful seroconversion following mild COVID-19 contraction in a double-vaccinated B-cell-depleted person with multiple sclerosis: A hint towards booster efficacy?
title_sort successful seroconversion following mild covid-19 contraction in a double-vaccinated b-cell-depleted person with multiple sclerosis: a hint towards booster efficacy?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634689/
http://dx.doi.org/10.1016/j.nerep.2021.100047
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