Cargando…

Discovery of 9,10-dihydrophenanthrene derivatives as SARS-CoV-2 3CL(pro) inhibitors for treating COVID-19

The epidemic coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has now spread worldwide and efficacious therapeutics are urgently needed. 3-Chymotrypsin-like cysteine protease (3CL(pro)) is an indispensable protein in viral replication and rep...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Jian-Wei, Xiong, Yuan, Wang, Feng, Zhang, Fu-Mao, Yang, Xiaodi, Lin, Guo-Qiang, Tian, Ping, Ge, Guangbo, Gao, Dingding
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Masson SAS. 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634693/ https://www.ncbi.nlm.nih.gov/pubmed/34883292 http://dx.doi.org/10.1016/j.ejmech.2021.114030

Ejemplares similares

Benzyl 3-(10-oxo-9,10-dihydrophenanthren-9-ylidene)dithiocarbazate
por: Liu, Qiao-Ru, et al.
Publicado: (2009)

3-Amino-1-methyl-9,10-dihydrophenanthrene-2,4-dicarbonitrile
por: Al-Youbi, Abdulrahman O., et al.
Publicado: (2011)

Rational identification of small molecules derived from 9,10-dihydrophenanthrene as potential inhibitors of 3CL(pro) enzyme for COVID-19 therapy: a computer-aided drug design approach
por: Daoui, Ossama, et al.
Publicado: (2022)

3-Amino-1-(thiophen-2-yl)-9,10-dihydrophenanthrene-2,4-dicarbonitrile
por: Al-Youbi, Abdulrahman O., et al.
Publicado: (2012)

3-Amino-1-(4-bromophenyl)-9,10-dihydrophenanthrene-2,4-dicarbonitrile
por: Asiri, Abdullah M., et al.
Publicado: (2011)

A New 9,10-Dihydrophenanthrene and Cell Proliferative 3,4-δ-Dehydrotocopherols from Stemona tuberosa
por: Kil, Yun-Seo, et al.
Publicado: (2015)

3-Amino-1-(4-methoxyphenyl)-9,10-dihydrophenanthrene-2,4-dicarbonitrile
por: Asiri, Abdullah M., et al.
Publicado: (2011)

An Efficient Approach to the Synthesis of Highly Congested 9,10-Dihydrophenanthrene-2,4-dicarbonitriles and Their Biological Evaluation as Antimicrobial Agents
por: Faidallah, Hassan M., et al.
Publicado: (2013)

[(E)-10-(2,6-Dimethylphenylimino)-9-methyl-9,10-dihydrophenanthren-9-olato]pentamethyldialuminum(III)
por: Gao, Bo, et al.
Publicado: (2011)

3-Amino-1-(3,4-dimethoxyphenyl)-9,10-dihydrophenanthrene-2,4-dicarbonitrile
por: Asiri, Abdullah M., et al.
Publicado: (2012)

9,10-Dihydrophenanthrene with Two Spiro(dibenzocycloheptatriene) Units: A Highly Strained Caged Hydrocarbon Exhibiting Reversible Electrochromic Behavior
por: Ishigaki, Yusuke, et al.
Publicado: (2017)

Exploring the Binding of Natural Compounds to Cancer-Related G-Quadruplex Structures: From 9,10-Dihydrophenanthrenes to Their Dimeric and Glucoside Derivatives
por: Platella, Chiara, et al.
Publicado: (2023)

9,10-Dimethyl-9,10-peroxy-9,10-dihydroanthracene
por: Wang, Yun-Wu
Publicado: (2008)

3-Amino-1-(2H-1,3-benzodioxol-5-yl)-9,10-dihydrophenanthrene-2,4-dicarbonitrile
por: Asiri, Abdullah M., et al.
Publicado: (2011)

(Z)-N-{(E)-10-[(2,6-Diisopropylphenyl)imino]-9,10-dihydrophenanthren-9-ylidene}-2,6-dimethylaniline
por: Li, Dongni, et al.
Publicado: (2012)

A second monoclinic polymorph for 3-amino-1-(4-methoxyphenyl)-9,10-dihydrophenanthrene-2,4-dicarbonitrile
por: Asiri, Abdullah M., et al.
Publicado: (2012)

N-Acetyl-N-[2,4-dicyano-1-(4-methoxyphenyl)-9,10-dihydrophenanthren-3-yl]acetamide
por: Asiri, Abdullah M., et al.
Publicado: (2012)

9,10-Dioxo-9,10-dihydroanthracene-1,4-diyl diacetate
por: Zhang, Jing-Jing, et al.
Publicado: (2013)

9,10-Diiodophenanthrene
por: Yokota, Ruri, et al.
Publicado: (2012)

9,10-Dibromophenanthrene
por: Yokota, Ruri, et al.
Publicado: (2012)

N,N′-Diphenyl-9,10-dioxo-9,10-dihydroanthracene-2,7-disulfonamide
por: Yuan, Wei-Guan, et al.
Publicado: (2013)

1,3-Dianionic annulation of ketones with ketene dithioacetal: a modified route to 3-aryl/cyclopropyl-5-thiomethyl-phenols and 1-(methylthio)-9,10-dihydrophenanthren-3-ols
por: Shaw, Ranjay, et al.
Publicado: (2023)

9,9-Dimethyl-9,10-dihydroanthracene
por: Siddaraju, B. P., et al.
Publicado: (2011)

4-(9,10-Dioxo-9,10-dihydroanthracen-1-yl)-4-oxobutanoic acid
por: Li, Yi, et al.
Publicado: (2010)

1,3-Dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carbaldehyde
por: Awang, Khalijah, et al.
Publicado: (2008)

2-Amino-4-phenyl-5,6-dihydrobenzo[h]quinoline-3-carbonitrile–3-amino-1-phenyl-9,10-dihydrophenanthrene-2,4-dicarbonitrile (5/3)
por: Asiri, Abdullah M., et al.
Publicado: (2011)

Facile Microwave-assisted Synthesis of 9,10-Dihydro-9,10-ethanoanthracene-11-carboxylic acid Methyl Ester
por: Phutdhawong, Weerachai, et al.
Publicado: (2005)

Ferrocenyl‐Pyrenes, Ferrocenyl‐9,10‐Phenanthrenediones, and Ferrocenyl‐9,10‐Dimethoxyphenanthrenes: Charge‐Transfer Studies and SWCNT Functionalization
por: Preuß, Andrea, et al.
Publicado: (2020)

Synthesis of 2-(9,10-Dihydro-9,10-propanoanthracen-9-yl)-N-methylethanamine via a [4+2] Cycloaddition
por: Karama, Usama, et al.
Publicado: (2010)

A Three‐Dimensional Inorganic Analogue of 9,10‐Diazido‐9,10‐Diboraanthracene: A Lewis Superacidic Azido Borane with Reactivity and Stability
por: Zhang, Chonghe, et al.
Publicado: (2022)

1-Dimethylamino-9,10-anthraquinone
por: Niedziałkowski, Paweł, et al.
Publicado: (2011)

Structural data of phenanthrene-9,10-dicarbonitriles
por: Afanasenko, Anastasiia M., et al.
Publicado: (2019)

11-Hydroxy-9-(prop-2-en-1-yl)-9,10-dihydro-9,10-propanoanthracen-12-one
por: Karama, Usama, et al.
Publicado: (2011)

N-(12-Amino-9,10-dihydro-9,10-ethanoanthracen-11-yl)-4-methylbenzenesulfonamide
por: Mague, Joel T., et al.
Publicado: (2014)

Crystal structure of 9,10-bis(1,3-dithiol-2-ylidene)-9,10-dihydroanthracene
por: Ren, Yi, et al.
Publicado: (2015)

Bis(1,10-phenanthrolin-1-ium) 9,10-dioxo-9,10-dihydroanthracene-1,5-disulfonate hexahydrate
por: Jia, Jia
Publicado: (2011)

2,6-Dimethoxy-9,10-anthraquinone
por: Ohta, Akira, et al.
Publicado: (2012)

1-(Piperidin-1-yl)-9,10-anthraquinone
por: Wnuk, Elżbieta, et al.
Publicado: (2012)

Mechanism for the photodegradation of 9,10-dibutoxyanthracene in the presence of air
por: Seto, Ryotaro, et al.
Publicado: (2022)

9,10-Bis(iodoethynyl)anthracene
por: Antoine, Nehemiah, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_47gsocbk7d82s8lu5rti113van