Brain Pathogenesis and Potential Therapeutic Strategies in Myotonic Dystrophy Type 1

Myotonic dystrophy type 1 (DM1) is the most common muscular dystrophy that affects multiple systems including the muscle and heart. The mutant CTG expansion at the 3′-UTR of the DMPK gene causes the expression of toxic RNA that aggregate as nuclear foci. The foci then interfere with RNA-binding prot...

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Detalles Bibliográficos
Autores principales: Liu, Jie, Guo, Zhen-Ni, Yan, Xiu-Li, Yang, Yi, Huang, Shuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Aging Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634727/
https://www.ncbi.nlm.nih.gov/pubmed/34867280
http://dx.doi.org/10.3389/fnagi.2021.755392

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