Ultrasound‐Triggered Delivery of Iproplatin from Microbubble‐Conjugated Liposomes

The Pt(IV) prodrug iproplatin has been actively loaded into liposomes using a calcium acetate gradient, achieving a 3‐fold enhancement in drug concentration compared to passive loading strategies. A strain‐promoted cycloaddition reaction (azide‐ dibenzocyclooctyne) was used to attach iproplatin‐load...

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Detalles Bibliográficos
Autores principales: Browning, Richard, Thomas, Nia, Marsh, Laura K., Tear, Louise R., Owen, Joshua, Stride, Eleanor, Farrer, Nicola J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634767/
https://www.ncbi.nlm.nih.gov/pubmed/34708552
http://dx.doi.org/10.1002/open.202100222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634767/
https://www.ncbi.nlm.nih.gov/pubmed/34708552
http://dx.doi.org/10.1002/open.202100222

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