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Altered Spontaneous Brain Activity Related to Neurologic and Sleep Dysfunction in Children With Obstructive Sleep Apnea Syndrome

Childhood obstructive sleep apnea (OSA) is a common chronic sleep-related breathing disorder in children, which leads to growth retardation, neurocognitive impairments, and serious complications. Considering the previous studies about brain structural abnormalities in OSA, in the present study, we a...

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Autores principales: Bai, Jie, Wen, Hongwei, Tai, Jun, Peng, Yun, Li, Hongbin, Mei, Lin, Ji, Tingting, Li, Xiaodan, Li, Yanhua, Ni, Xin, Liu, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634797/
https://www.ncbi.nlm.nih.gov/pubmed/34867137
http://dx.doi.org/10.3389/fnins.2021.595412
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author Bai, Jie
Wen, Hongwei
Tai, Jun
Peng, Yun
Li, Hongbin
Mei, Lin
Ji, Tingting
Li, Xiaodan
Li, Yanhua
Ni, Xin
Liu, Yue
author_facet Bai, Jie
Wen, Hongwei
Tai, Jun
Peng, Yun
Li, Hongbin
Mei, Lin
Ji, Tingting
Li, Xiaodan
Li, Yanhua
Ni, Xin
Liu, Yue
author_sort Bai, Jie
collection PubMed
description Childhood obstructive sleep apnea (OSA) is a common chronic sleep-related breathing disorder in children, which leads to growth retardation, neurocognitive impairments, and serious complications. Considering the previous studies about brain structural abnormalities in OSA, in the present study, we aimed to explore the altered spontaneous brain activity among OSA patients, using amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) methods based on resting-state functional magnetic resonance imaging (MRI). Thirty-one untreated OSA children and 33 age-and gender-matched healthy children (HC) were included in this study. Compared with controls, the OSA group showed significant lower ALFF in the right lingual gyrus, decreased fALFF in the left middle frontal gyrus (MFG), but increased fALFF in the left precuneus. Decreased ReHo was found in the left inferior frontal gyrus (orbital part) and left middle frontal gyrus. Notably, the mean fALFF value of left MFG was not only significantly related to multiple sleep parameters but also demonstrated the best performance in ROC curve analysis. These findings revealed OSA children were associated with dysfunctions in the default mode network, the frontal lobe, and the lingual gyrus, which may implicate the underlying neurophysiological mechanisms of intrinsic brain activity. The correlation between the altered spontaneous neuronal activity and the clinical index provides early useful diagnostic biomarkers for OSA children as well.
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spelling pubmed-86347972021-12-02 Altered Spontaneous Brain Activity Related to Neurologic and Sleep Dysfunction in Children With Obstructive Sleep Apnea Syndrome Bai, Jie Wen, Hongwei Tai, Jun Peng, Yun Li, Hongbin Mei, Lin Ji, Tingting Li, Xiaodan Li, Yanhua Ni, Xin Liu, Yue Front Neurosci Neuroscience Childhood obstructive sleep apnea (OSA) is a common chronic sleep-related breathing disorder in children, which leads to growth retardation, neurocognitive impairments, and serious complications. Considering the previous studies about brain structural abnormalities in OSA, in the present study, we aimed to explore the altered spontaneous brain activity among OSA patients, using amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) methods based on resting-state functional magnetic resonance imaging (MRI). Thirty-one untreated OSA children and 33 age-and gender-matched healthy children (HC) were included in this study. Compared with controls, the OSA group showed significant lower ALFF in the right lingual gyrus, decreased fALFF in the left middle frontal gyrus (MFG), but increased fALFF in the left precuneus. Decreased ReHo was found in the left inferior frontal gyrus (orbital part) and left middle frontal gyrus. Notably, the mean fALFF value of left MFG was not only significantly related to multiple sleep parameters but also demonstrated the best performance in ROC curve analysis. These findings revealed OSA children were associated with dysfunctions in the default mode network, the frontal lobe, and the lingual gyrus, which may implicate the underlying neurophysiological mechanisms of intrinsic brain activity. The correlation between the altered spontaneous neuronal activity and the clinical index provides early useful diagnostic biomarkers for OSA children as well. Frontiers Media S.A. 2021-11-15 /pmc/articles/PMC8634797/ /pubmed/34867137 http://dx.doi.org/10.3389/fnins.2021.595412 Text en Copyright © 2021 Bai, Wen, Tai, Peng, Li, Mei, Ji, Li, Li, Ni and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Bai, Jie
Wen, Hongwei
Tai, Jun
Peng, Yun
Li, Hongbin
Mei, Lin
Ji, Tingting
Li, Xiaodan
Li, Yanhua
Ni, Xin
Liu, Yue
Altered Spontaneous Brain Activity Related to Neurologic and Sleep Dysfunction in Children With Obstructive Sleep Apnea Syndrome
title Altered Spontaneous Brain Activity Related to Neurologic and Sleep Dysfunction in Children With Obstructive Sleep Apnea Syndrome
title_full Altered Spontaneous Brain Activity Related to Neurologic and Sleep Dysfunction in Children With Obstructive Sleep Apnea Syndrome
title_fullStr Altered Spontaneous Brain Activity Related to Neurologic and Sleep Dysfunction in Children With Obstructive Sleep Apnea Syndrome
title_full_unstemmed Altered Spontaneous Brain Activity Related to Neurologic and Sleep Dysfunction in Children With Obstructive Sleep Apnea Syndrome
title_short Altered Spontaneous Brain Activity Related to Neurologic and Sleep Dysfunction in Children With Obstructive Sleep Apnea Syndrome
title_sort altered spontaneous brain activity related to neurologic and sleep dysfunction in children with obstructive sleep apnea syndrome
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634797/
https://www.ncbi.nlm.nih.gov/pubmed/34867137
http://dx.doi.org/10.3389/fnins.2021.595412
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