Antinociceptive and Antipruritic Effects of HSK21542, a Peripherally-Restricted Kappa Opioid Receptor Agonist, in Animal Models of Pain and Itch

Kappa opioid receptor (KOR) agonists have been promising therapeutic candidates, owing to their potential for relieving pain and treating intractable pruritus. Although lacking morphine-like central nervous system (CNS) effects, KOR agonists do elicit sedation, dysphoria and diuresis which seriously...

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Detalles Bibliográficos
Autores principales: Wang, Xin, Gou, Xiaoli, Yu, Xiaojuan, Bai, Dongdong, Tan, Bowei, Cao, Pingfeng, Qian, Meilin, Zheng, Xiaoxiao, Wang, Hairong, Tang, Pingming, Zhang, Chen, Ye, Fei, Ni, Jia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635029/
https://www.ncbi.nlm.nih.gov/pubmed/34867403
http://dx.doi.org/10.3389/fphar.2021.773204

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