CRISPR Generated SIX6 and POU4F2 Reporters Allow Identification of Brain and Optic Transcriptional Differences in Human PSC-Derived Organoids

Human pluripotent stem cells (PSCs) represent a powerful tool to investigate human eye development and disease. When grown in 3D, they can self-assemble into laminar organized retinas; however, variation in the size, shape and composition of individual organoids exists. Neither the microenvironment...

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Detalles Bibliográficos
Autores principales: Wahlin, Karl J., Cheng, Jie, Jurlina, Shawna L., Jones, Melissa K., Dash, Nicholas R., Ogata, Anna, Kibria, Nawal, Ray, Sunayan, Eldred, Kiara C., Kim, Catherine, Heng, Jacob S., Phillips, Jenny, Johnston, Robert J., Gamm, David M., Berlinicke, Cynthia, Zack, Donald J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635054/
https://www.ncbi.nlm.nih.gov/pubmed/34869356
http://dx.doi.org/10.3389/fcell.2021.764725

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635054/
https://www.ncbi.nlm.nih.gov/pubmed/34869356
http://dx.doi.org/10.3389/fcell.2021.764725

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