Cargando…

CRISPR Generated SIX6 and POU4F2 Reporters Allow Identification of Brain and Optic Transcriptional Differences in Human PSC-Derived Organoids

Human pluripotent stem cells (PSCs) represent a powerful tool to investigate human eye development and disease. When grown in 3D, they can self-assemble into laminar organized retinas; however, variation in the size, shape and composition of individual organoids exists. Neither the microenvironment...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wahlin, Karl J., Cheng, Jie, Jurlina, Shawna L., Jones, Melissa K., Dash, Nicholas R., Ogata, Anna, Kibria, Nawal, Ray, Sunayan, Eldred, Kiara C., Kim, Catherine, Heng, Jacob S., Phillips, Jenny, Johnston, Robert J., Gamm, David M., Berlinicke, Cynthia, Zack, Donald J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635054/ https://www.ncbi.nlm.nih.gov/pubmed/34869356 http://dx.doi.org/10.3389/fcell.2021.764725

Ejemplares similares

Thyroid hormone signaling specifies cone subtypes in human retinal organoids
por: Eldred, Kiara C., et al.
Publicado: (2018)

Chromatin Accessibility and Transcriptional Differences in Human Stem Cell-Derived Early-Stage Retinal Organoids
por: Jones, Melissa K., et al.
Publicado: (2022)

RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors
por: Zhang, Ling, et al.
Publicado: (2013)

Investigating cone photoreceptor development using patient-derived NRL null retinal organoids
por: Kallman, Alyssa, et al.
Publicado: (2020)

Cornea organoids from human induced pluripotent stem cells
por: Foster, James W., et al.
Publicado: (2017)

A Tet-Inducible CRISPR Platform for High-Fidelity Editing of Human Pluripotent Stem Cells
por: Jurlina, Shawna L., et al.
Publicado: (2022)

Single-cell sequencing of individual retinal organoids reveals determinants of cell fate heterogeneity
por: Tresenrider, Amy, et al.
Publicado: (2023)

Single-cell sequencing of individual retinal organoids reveals determinants of cell-fate heterogeneity
por: Tresenrider, Amy, et al.
Publicado: (2023)

Expansion of the CRISPR-Cas9 genome targeting space through the use of H1 promoter-expressed guide–RNAs
por: Ranganathan, Vinod, et al.
Publicado: (2014)

Modeling binary and graded cone cell fate patterning in the mouse retina
por: Eldred, Kiara C., et al.
Publicado: (2020)

hPSC-derived organoids: models of human development and disease
por: Frum, Tristan, et al.
Publicado: (2020)

hPSC-derived lung organoids: Potential opportunities and challenges
por: Du, Xiaoli, et al.
Publicado: (2023)

Merits and challenges of iPSC-derived organoids for clinical applications
por: Xu, Ziran, et al.
Publicado: (2023)

Human iPSC colon organoid function is improved by exposure to fecal fermentates
por: Pearce, Sarah C., et al.
Publicado: (2022)

Correction to: hPSC-derived organoids: models of human development and disease
por: Frum, Tristan, et al.
Publicado: (2020)

iPSC-Derived Organoids as Therapeutic Models in Regenerative Medicine and Oncology
por: Turhan, Ali G., et al.
Publicado: (2021)

Application of an iPSC‐Derived Organoid Model for Localized Scleroderma Therapy
por: Ma, Jie, et al.
Publicado: (2022)

Characterization of the epidermal-dermal junction in hiPSC-derived skin organoids
por: Ramovs, Veronika, et al.
Publicado: (2022)

iPSC-derived mesenchymal cells that support alveolar organoid development
por: Tamai, Koji, et al.
Publicado: (2022)

“iPSC-derived liver organoids and inherited bleeding disorders: Potential and future perspectives”
por: Roman, Giacomo, et al.
Publicado: (2023)

PAX6-positive microglia evolve locally in hiPSC-derived ocular organoids
por: Shiraki, Nobuhiko, et al.
Publicado: (2022)

Modeling Human Cytomegalovirus-Induced Microcephaly in Human iPSC-Derived Brain Organoids
por: Sun, Guoqiang, et al.
Publicado: (2020)

Generation and validation of APOE knockout human iPSC-derived cerebral organoids
por: Martens, Yuka A., et al.
Publicado: (2021)

Generation of self-assembling cardiac organoids using hiPSC-derived cardiomyocytes
por: Künzel, Karolina, et al.
Publicado: (2022)

Modeling and Rescue of RP2 Retinitis Pigmentosa Using iPSC-Derived Retinal Organoids
por: Lane, Amelia, et al.
Publicado: (2020)

On the origin of POU5F1
por: Frankenberg, Stephen, et al.
Publicado: (2013)

Nanoblades allow high-level genome editing in murine and human organoids
por: Tiroille, Victor, et al.
Publicado: (2023)

The POU Transcription Factor POU-M2 Regulates Vitellogenin Receptor Gene Expression in the Silkworm, Bombyx mori
por: Shen, Guanwang, et al.
Publicado: (2020)

Amphetamine-Induced Sensitization Has Little Effect on Multiple Learning Paradigms and Fails to Rescue Mice with a Striatal Learning Defect
por: Eldred, Kiara C., et al.
Publicado: (2013)

Storable bFGF-Releasing Membrane Allowing Continuous Human iPSC Culture
por: Oyane, Ayako, et al.
Publicado: (2021)

The endothelium, a key actor in organ development and hPSC-derived organoid vascularization
por: Vargas-Valderrama, Alejandra, et al.
Publicado: (2020)

Advancing Drug Discovery for Neurological Disorders Using iPSC-Derived Neural Organoids
por: Costamagna, Gianluca, et al.
Publicado: (2021)

Sevoflurane promotes premature differentiation of dopaminergic neurons in hiPSC-derived midbrain organoids
por: Shang, Jia, et al.
Publicado: (2022)

iPSC-derived three-dimensional brain organoid models and neurotropic viral infections
por: Swingler, Michael, et al.
Publicado: (2023)

Human pluripotent stem cell (hPSC) and organoid models of autism: opportunities and limitations
por: Kilpatrick, Savannah, et al.
Publicado: (2023)

In depth characterization of midbrain organoids derived from wild type iPSC lines
por: Pavlinov, Ivan, et al.
Publicado: (2023)

Reliability of human retina organoid generation from hiPSC-derived neuroepithelial cysts
por: Carido, Madalena, et al.
Publicado: (2023)

Development of lacrimal gland organoids from iPSC derived multizonal ocular cells
por: Asal, Melis, et al.
Publicado: (2023)

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis
por: Samelson, Avi J., et al.
Publicado: (2023)

Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line
por: Sluch, Valentin M., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_1d3jlsnuvdlfdcumd6556m6pj1