Research Progress, Challenges, and Breakthroughs of Organoids as Disease Models

Traditional cell lines and xenograft models have been widely recognized and used in research. As a new research model, organoids have made significant progress and development in the past 10 years. Compared with traditional models, organoids have more advantages and have been applied in cancer resea...

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Autores principales: Huang, Yisheng, Huang, Zhijie, Tang, Zhengming, Chen, Yuanxin, Huang, Mingshu, Liu, Hongyu, Huang, Weibo, Ye, Qingsong, Jia, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635113/
https://www.ncbi.nlm.nih.gov/pubmed/34869324
http://dx.doi.org/10.3389/fcell.2021.740574
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author Huang, Yisheng
Huang, Zhijie
Tang, Zhengming
Chen, Yuanxin
Huang, Mingshu
Liu, Hongyu
Huang, Weibo
Ye, Qingsong
Jia, Bo
author_facet Huang, Yisheng
Huang, Zhijie
Tang, Zhengming
Chen, Yuanxin
Huang, Mingshu
Liu, Hongyu
Huang, Weibo
Ye, Qingsong
Jia, Bo
author_sort Huang, Yisheng
collection PubMed
description Traditional cell lines and xenograft models have been widely recognized and used in research. As a new research model, organoids have made significant progress and development in the past 10 years. Compared with traditional models, organoids have more advantages and have been applied in cancer research, genetic diseases, infectious diseases, and regenerative medicine. This review presented the advantages and disadvantages of organoids in physiological development, pathological mechanism, drug screening, and organ transplantation. Further, this review summarized the current situation of vascularization, immune microenvironment, and hydrogel, which are the main influencing factors of organoids, and pointed out the future directions of development.
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spelling pubmed-86351132021-12-02 Research Progress, Challenges, and Breakthroughs of Organoids as Disease Models Huang, Yisheng Huang, Zhijie Tang, Zhengming Chen, Yuanxin Huang, Mingshu Liu, Hongyu Huang, Weibo Ye, Qingsong Jia, Bo Front Cell Dev Biol Cell and Developmental Biology Traditional cell lines and xenograft models have been widely recognized and used in research. As a new research model, organoids have made significant progress and development in the past 10 years. Compared with traditional models, organoids have more advantages and have been applied in cancer research, genetic diseases, infectious diseases, and regenerative medicine. This review presented the advantages and disadvantages of organoids in physiological development, pathological mechanism, drug screening, and organ transplantation. Further, this review summarized the current situation of vascularization, immune microenvironment, and hydrogel, which are the main influencing factors of organoids, and pointed out the future directions of development. Frontiers Media S.A. 2021-11-16 /pmc/articles/PMC8635113/ /pubmed/34869324 http://dx.doi.org/10.3389/fcell.2021.740574 Text en Copyright © 2021 Huang, Huang, Tang, Chen, Huang, Liu, Huang, Ye and Jia. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Huang, Yisheng
Huang, Zhijie
Tang, Zhengming
Chen, Yuanxin
Huang, Mingshu
Liu, Hongyu
Huang, Weibo
Ye, Qingsong
Jia, Bo
Research Progress, Challenges, and Breakthroughs of Organoids as Disease Models
title Research Progress, Challenges, and Breakthroughs of Organoids as Disease Models
title_full Research Progress, Challenges, and Breakthroughs of Organoids as Disease Models
title_fullStr Research Progress, Challenges, and Breakthroughs of Organoids as Disease Models
title_full_unstemmed Research Progress, Challenges, and Breakthroughs of Organoids as Disease Models
title_short Research Progress, Challenges, and Breakthroughs of Organoids as Disease Models
title_sort research progress, challenges, and breakthroughs of organoids as disease models
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635113/
https://www.ncbi.nlm.nih.gov/pubmed/34869324
http://dx.doi.org/10.3389/fcell.2021.740574
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