Tissue Engineering Strategies for Peripheral Nerve Regeneration

A peripheral nerve injury (PNI) has severe and profound effects on the life of a patient. The therapeutic approach remains one of the most challenging clinical problems. In recent years, many constructive nerve regeneration schemes are proposed at home and abroad. Nerve tissue engineering plays an i...

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Detalles Bibliográficos
Autores principales: Li, Yin, Ma, Zhenjiang, Ren, Ya, Lu, Dezhi, Li, Tao, Li, Wentao, Wang, Jinwu, Ma, Hui, Zhao, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635143/
https://www.ncbi.nlm.nih.gov/pubmed/34867754
http://dx.doi.org/10.3389/fneur.2021.768267
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author Li, Yin
Ma, Zhenjiang
Ren, Ya
Lu, Dezhi
Li, Tao
Li, Wentao
Wang, Jinwu
Ma, Hui
Zhao, Jie
author_facet Li, Yin
Ma, Zhenjiang
Ren, Ya
Lu, Dezhi
Li, Tao
Li, Wentao
Wang, Jinwu
Ma, Hui
Zhao, Jie
author_sort Li, Yin
collection PubMed
description A peripheral nerve injury (PNI) has severe and profound effects on the life of a patient. The therapeutic approach remains one of the most challenging clinical problems. In recent years, many constructive nerve regeneration schemes are proposed at home and abroad. Nerve tissue engineering plays an important role. It develops an ideal nerve substitute called artificial nerve. Given the complexity of nerve regeneration, this review summarizes the pathophysiology and tissue-engineered repairing strategies of the PNI. Moreover, we discussed the scaffolds and seed cells for neural tissue engineering. Furthermore, we have emphasized the role of 3D printing in tissue engineering.
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spelling pubmed-86351432021-12-02 Tissue Engineering Strategies for Peripheral Nerve Regeneration Li, Yin Ma, Zhenjiang Ren, Ya Lu, Dezhi Li, Tao Li, Wentao Wang, Jinwu Ma, Hui Zhao, Jie Front Neurol Neurology A peripheral nerve injury (PNI) has severe and profound effects on the life of a patient. The therapeutic approach remains one of the most challenging clinical problems. In recent years, many constructive nerve regeneration schemes are proposed at home and abroad. Nerve tissue engineering plays an important role. It develops an ideal nerve substitute called artificial nerve. Given the complexity of nerve regeneration, this review summarizes the pathophysiology and tissue-engineered repairing strategies of the PNI. Moreover, we discussed the scaffolds and seed cells for neural tissue engineering. Furthermore, we have emphasized the role of 3D printing in tissue engineering. Frontiers Media S.A. 2021-11-16 /pmc/articles/PMC8635143/ /pubmed/34867754 http://dx.doi.org/10.3389/fneur.2021.768267 Text en Copyright © 2021 Li, Ma, Ren, Lu, Li, Li, Wang, Ma and Zhao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Li, Yin
Ma, Zhenjiang
Ren, Ya
Lu, Dezhi
Li, Tao
Li, Wentao
Wang, Jinwu
Ma, Hui
Zhao, Jie
Tissue Engineering Strategies for Peripheral Nerve Regeneration
title Tissue Engineering Strategies for Peripheral Nerve Regeneration
title_full Tissue Engineering Strategies for Peripheral Nerve Regeneration
title_fullStr Tissue Engineering Strategies for Peripheral Nerve Regeneration
title_full_unstemmed Tissue Engineering Strategies for Peripheral Nerve Regeneration
title_short Tissue Engineering Strategies for Peripheral Nerve Regeneration
title_sort tissue engineering strategies for peripheral nerve regeneration
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635143/
https://www.ncbi.nlm.nih.gov/pubmed/34867754
http://dx.doi.org/10.3389/fneur.2021.768267
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