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Agritourism and Kidding Season: A Large Outbreak of Human Shiga Toxin-Producing Escherichia coli O157 (STEC O157) Infections Linked to a Goat Dairy Farm—Connecticut, 2016

The objective of this study was to determine sources of Shiga toxin-producing Escherichia coli O157 (STEC O157) infection among visitors to Farm X and develop public health recommendations. A case-control study was conducted. Case-patients were defined as the first ill child (aged <18 years) in t...

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Autores principales: Nichols, Megin C., Gacek, Paul, Phan, Quyen, Gambino-Shirley, Kelly J., Gollarza, Lauren M., Schroeder, Morgan N., Mercante, Alexandra, Mullins, Jocelyn, Blackstock, Anna, Laughlin, Mark E., Olson, Samantha M., Pizzo, Eugene, Nguyen, Tu Ngoc, Mank, Laurn, Holmes-Talbot, Kimberly, McNutt, Alycia, Noel, Diane, Muyombwe, Anthony, Razeq, Jafar H., Lis, Mary Jane, Sherman, Bruce, Kasacek, Wayne, Whitlock, Laura, Strockbine, Nancy, Martin, Haley, Vidyaprakash, Eshaw, McCormack, Patrick, Cartter, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635155/
https://www.ncbi.nlm.nih.gov/pubmed/34869720
http://dx.doi.org/10.3389/fvets.2021.744055
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author Nichols, Megin C.
Gacek, Paul
Phan, Quyen
Gambino-Shirley, Kelly J.
Gollarza, Lauren M.
Schroeder, Morgan N.
Mercante, Alexandra
Mullins, Jocelyn
Blackstock, Anna
Laughlin, Mark E.
Olson, Samantha M.
Pizzo, Eugene
Nguyen, Tu Ngoc
Mank, Laurn
Holmes-Talbot, Kimberly
McNutt, Alycia
Noel, Diane
Muyombwe, Anthony
Razeq, Jafar H.
Lis, Mary Jane
Sherman, Bruce
Kasacek, Wayne
Whitlock, Laura
Strockbine, Nancy
Martin, Haley
Vidyaprakash, Eshaw
McCormack, Patrick
Cartter, Matthew
author_facet Nichols, Megin C.
Gacek, Paul
Phan, Quyen
Gambino-Shirley, Kelly J.
Gollarza, Lauren M.
Schroeder, Morgan N.
Mercante, Alexandra
Mullins, Jocelyn
Blackstock, Anna
Laughlin, Mark E.
Olson, Samantha M.
Pizzo, Eugene
Nguyen, Tu Ngoc
Mank, Laurn
Holmes-Talbot, Kimberly
McNutt, Alycia
Noel, Diane
Muyombwe, Anthony
Razeq, Jafar H.
Lis, Mary Jane
Sherman, Bruce
Kasacek, Wayne
Whitlock, Laura
Strockbine, Nancy
Martin, Haley
Vidyaprakash, Eshaw
McCormack, Patrick
Cartter, Matthew
author_sort Nichols, Megin C.
collection PubMed
description The objective of this study was to determine sources of Shiga toxin-producing Escherichia coli O157 (STEC O157) infection among visitors to Farm X and develop public health recommendations. A case-control study was conducted. Case-patients were defined as the first ill child (aged <18 years) in the household with laboratory-confirmed STEC O157, or physician-diagnosed hemolytic uremic syndrome with laboratory confirmation by serology, who visited Farm X in the 10 days prior to illness. Controls were selected from Farm X visitors aged <18 years, without symptoms during the same time period as case-patients. Environment and animal fecal samples collected from Farm X were cultured; isolates from Farm X were compared with patient isolates using whole genome sequencing (WGS). Case-patients were more likely than controls to have sat on hay bales at the doe barn (adjusted odds ratio: 4.55; 95% confidence interval: 1.41–16.13). No handwashing stations were available; limited hand sanitizer was provided. Overall, 37% (29 of 78) of animal and environmental samples collected were positive for STEC; of these, 62% (18 of 29) yielded STEC O157 highly related by WGS to patient isolates. STEC O157 environmental contamination and fecal shedding by goats at Farm X was extensive. Farms should provide handwashing stations with soap, running water, and disposable towels. Access to animal areas, including animal pens and enclosures, should be limited for young children who are at risk for severe outcomes from STEC O157 infection. National recommendations should be adopted to reduce disease transmission.
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spelling pubmed-86351552021-12-02 Agritourism and Kidding Season: A Large Outbreak of Human Shiga Toxin-Producing Escherichia coli O157 (STEC O157) Infections Linked to a Goat Dairy Farm—Connecticut, 2016 Nichols, Megin C. Gacek, Paul Phan, Quyen Gambino-Shirley, Kelly J. Gollarza, Lauren M. Schroeder, Morgan N. Mercante, Alexandra Mullins, Jocelyn Blackstock, Anna Laughlin, Mark E. Olson, Samantha M. Pizzo, Eugene Nguyen, Tu Ngoc Mank, Laurn Holmes-Talbot, Kimberly McNutt, Alycia Noel, Diane Muyombwe, Anthony Razeq, Jafar H. Lis, Mary Jane Sherman, Bruce Kasacek, Wayne Whitlock, Laura Strockbine, Nancy Martin, Haley Vidyaprakash, Eshaw McCormack, Patrick Cartter, Matthew Front Vet Sci Veterinary Science The objective of this study was to determine sources of Shiga toxin-producing Escherichia coli O157 (STEC O157) infection among visitors to Farm X and develop public health recommendations. A case-control study was conducted. Case-patients were defined as the first ill child (aged <18 years) in the household with laboratory-confirmed STEC O157, or physician-diagnosed hemolytic uremic syndrome with laboratory confirmation by serology, who visited Farm X in the 10 days prior to illness. Controls were selected from Farm X visitors aged <18 years, without symptoms during the same time period as case-patients. Environment and animal fecal samples collected from Farm X were cultured; isolates from Farm X were compared with patient isolates using whole genome sequencing (WGS). Case-patients were more likely than controls to have sat on hay bales at the doe barn (adjusted odds ratio: 4.55; 95% confidence interval: 1.41–16.13). No handwashing stations were available; limited hand sanitizer was provided. Overall, 37% (29 of 78) of animal and environmental samples collected were positive for STEC; of these, 62% (18 of 29) yielded STEC O157 highly related by WGS to patient isolates. STEC O157 environmental contamination and fecal shedding by goats at Farm X was extensive. Farms should provide handwashing stations with soap, running water, and disposable towels. Access to animal areas, including animal pens and enclosures, should be limited for young children who are at risk for severe outcomes from STEC O157 infection. National recommendations should be adopted to reduce disease transmission. Frontiers Media S.A. 2021-11-16 /pmc/articles/PMC8635155/ /pubmed/34869720 http://dx.doi.org/10.3389/fvets.2021.744055 Text en Copyright © 2021 Nichols, Gacek, Phan, Gambino-Shirley, Gollarza, Schroeder, Mercante, Mullins, Blackstock, Laughlin, Olson, Pizzo, Nguyen, Mank, Holmes-Talbot, McNutt, Noel, Muyombwe, Razeq, Lis, Sherman, Kasacek, Whitlock, Strockbine, Martin, Vidyaprakash, McCormack and Cartter. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Nichols, Megin C.
Gacek, Paul
Phan, Quyen
Gambino-Shirley, Kelly J.
Gollarza, Lauren M.
Schroeder, Morgan N.
Mercante, Alexandra
Mullins, Jocelyn
Blackstock, Anna
Laughlin, Mark E.
Olson, Samantha M.
Pizzo, Eugene
Nguyen, Tu Ngoc
Mank, Laurn
Holmes-Talbot, Kimberly
McNutt, Alycia
Noel, Diane
Muyombwe, Anthony
Razeq, Jafar H.
Lis, Mary Jane
Sherman, Bruce
Kasacek, Wayne
Whitlock, Laura
Strockbine, Nancy
Martin, Haley
Vidyaprakash, Eshaw
McCormack, Patrick
Cartter, Matthew
Agritourism and Kidding Season: A Large Outbreak of Human Shiga Toxin-Producing Escherichia coli O157 (STEC O157) Infections Linked to a Goat Dairy Farm—Connecticut, 2016
title Agritourism and Kidding Season: A Large Outbreak of Human Shiga Toxin-Producing Escherichia coli O157 (STEC O157) Infections Linked to a Goat Dairy Farm—Connecticut, 2016
title_full Agritourism and Kidding Season: A Large Outbreak of Human Shiga Toxin-Producing Escherichia coli O157 (STEC O157) Infections Linked to a Goat Dairy Farm—Connecticut, 2016
title_fullStr Agritourism and Kidding Season: A Large Outbreak of Human Shiga Toxin-Producing Escherichia coli O157 (STEC O157) Infections Linked to a Goat Dairy Farm—Connecticut, 2016
title_full_unstemmed Agritourism and Kidding Season: A Large Outbreak of Human Shiga Toxin-Producing Escherichia coli O157 (STEC O157) Infections Linked to a Goat Dairy Farm—Connecticut, 2016
title_short Agritourism and Kidding Season: A Large Outbreak of Human Shiga Toxin-Producing Escherichia coli O157 (STEC O157) Infections Linked to a Goat Dairy Farm—Connecticut, 2016
title_sort agritourism and kidding season: a large outbreak of human shiga toxin-producing escherichia coli o157 (stec o157) infections linked to a goat dairy farm—connecticut, 2016
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635155/
https://www.ncbi.nlm.nih.gov/pubmed/34869720
http://dx.doi.org/10.3389/fvets.2021.744055
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