Cargando…

Mesoporous Silica Nanoparticle-Based Imaging Agents for Hepatocellular Carcinoma Detection

Hepatocellular carcinoma (HCC) is characterized by poor prognosis and high mortality. The treatment of HCC is closely related to the stage, and the early-stage of HCC patients usually accompanies a more long-term survival rate after clinical treatment. Hence, there are critical needs to develop effe...

Descripción completa

Detalles Bibliográficos
Autores principales: Peng, Xuqi, Lin, Gan, Zeng, Yun, Lei, Zhao, Liu, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635232/
https://www.ncbi.nlm.nih.gov/pubmed/34869261
http://dx.doi.org/10.3389/fbioe.2021.749381
_version_ 1784608261532549120
author Peng, Xuqi
Lin, Gan
Zeng, Yun
Lei, Zhao
Liu, Gang
author_facet Peng, Xuqi
Lin, Gan
Zeng, Yun
Lei, Zhao
Liu, Gang
author_sort Peng, Xuqi
collection PubMed
description Hepatocellular carcinoma (HCC) is characterized by poor prognosis and high mortality. The treatment of HCC is closely related to the stage, and the early-stage of HCC patients usually accompanies a more long-term survival rate after clinical treatment. Hence, there are critical needs to develop effective imaging agents with superior diagnostic precision for HCC detection at an early stage. Recently, mesoporous silica nanoparticles (MSNs) based imaging agents have gained extensive attentions in HCC detection, which can serve as a multifunctional nanoplatform with controllable size and facile surface functionalization. This perspective summarizes recent advances in MSNs based imaging agents for HCC detection by the incorporation of several clinical imaging modalities. Multi-modal imaging system has been developed for higher spatial resolution and sensitivity. Even though some limitations and challenges need to be overcome, we envision the development of novel MSNs based imaging agents will offer great potential applications in clinical HCC detection.
format Online
Article
Text
id pubmed-8635232
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-86352322021-12-02 Mesoporous Silica Nanoparticle-Based Imaging Agents for Hepatocellular Carcinoma Detection Peng, Xuqi Lin, Gan Zeng, Yun Lei, Zhao Liu, Gang Front Bioeng Biotechnol Bioengineering and Biotechnology Hepatocellular carcinoma (HCC) is characterized by poor prognosis and high mortality. The treatment of HCC is closely related to the stage, and the early-stage of HCC patients usually accompanies a more long-term survival rate after clinical treatment. Hence, there are critical needs to develop effective imaging agents with superior diagnostic precision for HCC detection at an early stage. Recently, mesoporous silica nanoparticles (MSNs) based imaging agents have gained extensive attentions in HCC detection, which can serve as a multifunctional nanoplatform with controllable size and facile surface functionalization. This perspective summarizes recent advances in MSNs based imaging agents for HCC detection by the incorporation of several clinical imaging modalities. Multi-modal imaging system has been developed for higher spatial resolution and sensitivity. Even though some limitations and challenges need to be overcome, we envision the development of novel MSNs based imaging agents will offer great potential applications in clinical HCC detection. Frontiers Media S.A. 2021-11-16 /pmc/articles/PMC8635232/ /pubmed/34869261 http://dx.doi.org/10.3389/fbioe.2021.749381 Text en Copyright © 2021 Peng, Lin, Zeng, Lei and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Peng, Xuqi
Lin, Gan
Zeng, Yun
Lei, Zhao
Liu, Gang
Mesoporous Silica Nanoparticle-Based Imaging Agents for Hepatocellular Carcinoma Detection
title Mesoporous Silica Nanoparticle-Based Imaging Agents for Hepatocellular Carcinoma Detection
title_full Mesoporous Silica Nanoparticle-Based Imaging Agents for Hepatocellular Carcinoma Detection
title_fullStr Mesoporous Silica Nanoparticle-Based Imaging Agents for Hepatocellular Carcinoma Detection
title_full_unstemmed Mesoporous Silica Nanoparticle-Based Imaging Agents for Hepatocellular Carcinoma Detection
title_short Mesoporous Silica Nanoparticle-Based Imaging Agents for Hepatocellular Carcinoma Detection
title_sort mesoporous silica nanoparticle-based imaging agents for hepatocellular carcinoma detection
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635232/
https://www.ncbi.nlm.nih.gov/pubmed/34869261
http://dx.doi.org/10.3389/fbioe.2021.749381
work_keys_str_mv AT pengxuqi mesoporoussilicananoparticlebasedimagingagentsforhepatocellularcarcinomadetection
AT lingan mesoporoussilicananoparticlebasedimagingagentsforhepatocellularcarcinomadetection
AT zengyun mesoporoussilicananoparticlebasedimagingagentsforhepatocellularcarcinomadetection
AT leizhao mesoporoussilicananoparticlebasedimagingagentsforhepatocellularcarcinomadetection
AT liugang mesoporoussilicananoparticlebasedimagingagentsforhepatocellularcarcinomadetection