Cargando…

Protection of ischemic white matter and oligodendrocytes in mice by 3K3A-activated protein C

Subcortical white matter (WM) stroke accounts for 25% of all strokes and is the second leading cause of dementia. Despite such clinical importance, we still do not have an effective treatment for ischemic WM stroke, and the mechanisms of WM postischemic neuroprotection remain elusive. 3K3A-activated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huuskonen, Mikko T., Wang, Yaoming, Nikolakopoulou, Angeliki Maria, Montagne, Axel, Dai, Zhonghua, Lazic, Divna, Sagare, Abhay P., Zhao, Zhen, Fernandez, Jose A., Griffin, John H., Zlokovic, Berislav V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635278/ https://www.ncbi.nlm.nih.gov/pubmed/34846535 http://dx.doi.org/10.1084/jem.20211372

Ejemplares similares

3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice
por: Lazic, Divna, et al.
Publicado: (2019)

Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss
por: Nikolakopoulou, Angeliki M., et al.
Publicado: (2019)

Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A
por: Nikolakopoulou, Angeliki Maria, et al.
Publicado: (2021)

3K3A-Activated Protein C Protects the Blood-Brain Barrier and Neurons From Accelerated Ischemic Injury Caused by Pericyte Deficiency in Mice
por: Wang, Yaoming, et al.
Publicado: (2022)

Acute Ablation of Cortical Pericytes Leads to Rapid Neurovascular Uncoupling
por: Kisler, Kassandra, et al.
Publicado: (2020)

Corrigendum: Acute ablation of cortical pericytes leads to rapid neurovascular uncoupling
por: Kisler, Kassandra, et al.
Publicado: (2022)

Regional early and progressive loss of brain pericytes but not vascular smooth muscle cells in adult mice with disrupted platelet-derived growth factor receptor-β signaling
por: Nikolakopoulou, Angeliki Maria, et al.
Publicado: (2017)

A “multi-omics” analysis of blood–brain barrier and synaptic dysfunction in APOE4 mice
por: Barisano, Giuseppe, et al.
Publicado: (2022)

Correction: Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier
por: Kisler, Kassandra, et al.
Publicado: (2023)

Anti-malaria drug artesunate prevents development of amyloid-β pathology in mice by upregulating PICALM at the blood-brain barrier
por: Kisler, Kassandra, et al.
Publicado: (2023)

Air Pollution Particulate Matter Amplifies White Matter Vascular Pathology and Demyelination Caused by Hypoperfusion
por: Huuskonen, Mikko T., et al.
Publicado: (2021)

Alzheimer’s disease: A matter of blood–brain barrier dysfunction?
por: Montagne, Axel, et al.
Publicado: (2017)

Cerebrospinal fluid biomarkers of neurovascular dysfunction in mild dementia and Alzheimer's disease
por: Sweeney, Melanie D, et al.
Publicado: (2015)

Microglia have a grip on brain microvasculature
por: Kisler, Kassandra, et al.
Publicado: (2021)

Impaired vascular-mediated clearance of brain amyloid beta in Alzheimer’s disease: the role, regulation and restoration of LRP1
por: Ramanathan, Anita, et al.
Publicado: (2015)

Air Pollution Particulate Matter Exposure and Chronic Cerebral Hypoperfusion and Measures of White Matter Injury in a Murine Model
por: Liu, Qinghai, et al.
Publicado: (2021)

Combined neurothrombectomy or thrombolysis with adjunctive delivery of 3K3A-activated protein C in acute ischemic stroke
por: Amar, Arun Paul, et al.
Publicado: (2015)

Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain in vivo
por: Nelson, Amy R., et al.
Publicado: (2020)

Magnetic resonance imaging of white matter response to diesel exhaust particles
por: Chakhoyan, Ararat, et al.
Publicado: (2023)

Brain barriers and their potential role in migraine pathophysiology
por: Wiggers, Astrid, et al.
Publicado: (2022)

Evidence that blood–CSF barrier transport, but not inflammatory biomarkers, change in migraine, while CSF sVCAM1 associates with migraine frequency and CSF fibrinogen
por: Cowan, Robert P., et al.
Publicado: (2021)

Pericyte loss influences Alzheimer-like neurodegeneration in mice
por: Sagare, Abhay P., et al.
Publicado: (2013)

Author Correction: Pericyte loss influences Alzheimer-like neurodegeneration in mice
por: Sagare, Abhay P., et al.
Publicado: (2023)

Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain
por: Kisler, Kassandra, et al.
Publicado: (2017)

A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease
por: Stringer, Michael S., et al.
Publicado: (2020)

Astrocytes in Oligodendrocyte Lineage Development and White Matter Pathology
por: Li, Jiasi, et al.
Publicado: (2016)

Oligodendrocyte Development and Implication in Perinatal White Matter Injury
por: Motavaf, Mahsa, et al.
Publicado: (2021)

White Matter Damage in Alzheimer’s Disease: Contribution of Oligodendrocytes
por: Zhou, Jinyu, et al.
Publicado: (2022)

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism
por: Ma, Qingyi, et al.
Publicado: (2018)

Correction: Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism
por: Ma, Qingyi, et al.
Publicado: (2022)

Toll-like Receptor 2: A Novel Therapeutic Target for Ischemic White Matter Injury and Oligodendrocyte Death
por: Choi, Jun Young, et al.
Publicado: (2017)

Histamine H(2) receptor negatively regulates oligodendrocyte differentiation in neonatal hypoxic-ischemic white matter injury
por: Jiang, Lei, et al.
Publicado: (2020)

ROCKETSHIP: a flexible and modular software tool for the planning, processing and analysis of dynamic MRI studies
por: Barnes, Samuel R., et al.
Publicado: (2015)

25.1 OLIGODENDROCYTE PATHOLOGY IN PREFRONTAL WHITE MATTER IN SCHIZOPHRENIA
por: Uranova, Natalya, et al.
Publicado: (2018)

Molecular Mechanisms of Oligodendrocyte Regeneration in White Matter-Related Diseases
por: Ohtomo, Ryo, et al.
Publicado: (2018)

Oligodendrocytes control potassium accumulation in white matter and seizure susceptibility
por: Larson, Valerie A, et al.
Publicado: (2018)

White-matter repair: Interaction between oligodendrocytes and the neurovascular unit
por: Hamanaka, Gen, et al.
Publicado: (2018)

10.2 REDOX DYSREGULATION, OLIGODENDROCYTES AND WHITE MATTER ALTERATIONS IN SCHIZOPHRENIA
por: Klauser, Paul, et al.
Publicado: (2018)

White matter changes in Alzheimer’s disease: a focus on myelin and oligodendrocytes
por: Nasrabady, Sara E., et al.
Publicado: (2018)

Ultrastructural pathology of oligodendrocytes adjacent to microglia in prefrontal white matter in schizophrenia
por: Uranova, Natalya A., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_iio741cv8qi1u7d5efm8buphks