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Hematological malignancies in the Northwest Ethiopia

BACKGROUND: The effect of malignant diseases is increasing globally, particularly in developing countries as shown by recent cancer statistics from the world health organization reports. It is anticipated that with an increase in life expectancy consequent upon the improved standard of living and in...

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Autores principales: Enawgaw, Bamlaku, Aynalem, Melak, Melku, Mulugeta, Asrie, Fikir, Abebe, Molla, Yalew, Aregawi, Bekele, Tiruzer, Mesfin, Nebiyu, Ayalew, Mulugeta, Shiferaw, Elias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635328/
https://www.ncbi.nlm.nih.gov/pubmed/34852010
http://dx.doi.org/10.1371/journal.pone.0260639
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author Enawgaw, Bamlaku
Aynalem, Melak
Melku, Mulugeta
Asrie, Fikir
Abebe, Molla
Yalew, Aregawi
Bekele, Tiruzer
Mesfin, Nebiyu
Ayalew, Mulugeta
Shiferaw, Elias
author_facet Enawgaw, Bamlaku
Aynalem, Melak
Melku, Mulugeta
Asrie, Fikir
Abebe, Molla
Yalew, Aregawi
Bekele, Tiruzer
Mesfin, Nebiyu
Ayalew, Mulugeta
Shiferaw, Elias
author_sort Enawgaw, Bamlaku
collection PubMed
description BACKGROUND: The effect of malignant diseases is increasing globally, particularly in developing countries as shown by recent cancer statistics from the world health organization reports. It is anticipated that with an increase in life expectancy consequent upon the improved standard of living and increasing urbanization, the burden of hematological malignancies in sub-Saharan Africa particularly in Ethiopia is likely to increase recently. Therefore, this study was aimed to determine the incidence and trend of hematological malignancy in Northwest Ethiopia. METHODS: A facility-based retrospective study was conducted from 2015 to 2019 at the University of Gondar and Bahir-Dar Felegehiwot comprehensive specialized hospitals. Hematological malignancy data were collected by using a data collection sheet that was consisted of patients’ socio-demography, clinical, and laboratory data. Then, data were entered into Epi-info 3.5.1 and exported to SPSS version 20 for analysis. Skewness and kurtosis were used to check data distribution. Descriptive statistics were summarized as percentages, means, and standard deviations of background variables, and the trend were analyzed. RESULTS: In this study, a total of 1,342 study participants were included. The mean age of study participants was 41.49 ± 16.3 years with a range of 1 to 92 years. About 58.3%, 52.2%, and 80% of the cases were observed among males, 18–45 age group, and urban residences, respectively. Of the total cases, 92.9% and 7.1% were lymphoma and leukemia, respectively. On the other hand, from lymphoma cases, 72.3% and 27.7% were HL and NHL, respectively while from leukemic cases, 61.1%, 23.2, 6.3%, 4.2%, and 5.3% were CLL, ALL, CML, AML, and other HM types, respectively. In this study, there was no trend. CONCLUSION: We concluded that lymphoma was the dominant type of hematological malignancy observed in northwest Ethiopia. The study indicated that the majority of cases were observed among male, urban residents, and adult populations aged 18–45 years. Therefore, special focus should be given to the highly affected population. Further, a prospective cohort study should be conducted for a better understanding of the prevalence and associated factors to it.
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spelling pubmed-86353282021-12-02 Hematological malignancies in the Northwest Ethiopia Enawgaw, Bamlaku Aynalem, Melak Melku, Mulugeta Asrie, Fikir Abebe, Molla Yalew, Aregawi Bekele, Tiruzer Mesfin, Nebiyu Ayalew, Mulugeta Shiferaw, Elias PLoS One Research Article BACKGROUND: The effect of malignant diseases is increasing globally, particularly in developing countries as shown by recent cancer statistics from the world health organization reports. It is anticipated that with an increase in life expectancy consequent upon the improved standard of living and increasing urbanization, the burden of hematological malignancies in sub-Saharan Africa particularly in Ethiopia is likely to increase recently. Therefore, this study was aimed to determine the incidence and trend of hematological malignancy in Northwest Ethiopia. METHODS: A facility-based retrospective study was conducted from 2015 to 2019 at the University of Gondar and Bahir-Dar Felegehiwot comprehensive specialized hospitals. Hematological malignancy data were collected by using a data collection sheet that was consisted of patients’ socio-demography, clinical, and laboratory data. Then, data were entered into Epi-info 3.5.1 and exported to SPSS version 20 for analysis. Skewness and kurtosis were used to check data distribution. Descriptive statistics were summarized as percentages, means, and standard deviations of background variables, and the trend were analyzed. RESULTS: In this study, a total of 1,342 study participants were included. The mean age of study participants was 41.49 ± 16.3 years with a range of 1 to 92 years. About 58.3%, 52.2%, and 80% of the cases were observed among males, 18–45 age group, and urban residences, respectively. Of the total cases, 92.9% and 7.1% were lymphoma and leukemia, respectively. On the other hand, from lymphoma cases, 72.3% and 27.7% were HL and NHL, respectively while from leukemic cases, 61.1%, 23.2, 6.3%, 4.2%, and 5.3% were CLL, ALL, CML, AML, and other HM types, respectively. In this study, there was no trend. CONCLUSION: We concluded that lymphoma was the dominant type of hematological malignancy observed in northwest Ethiopia. The study indicated that the majority of cases were observed among male, urban residents, and adult populations aged 18–45 years. Therefore, special focus should be given to the highly affected population. Further, a prospective cohort study should be conducted for a better understanding of the prevalence and associated factors to it. Public Library of Science 2021-12-01 /pmc/articles/PMC8635328/ /pubmed/34852010 http://dx.doi.org/10.1371/journal.pone.0260639 Text en © 2021 Enawgaw et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Enawgaw, Bamlaku
Aynalem, Melak
Melku, Mulugeta
Asrie, Fikir
Abebe, Molla
Yalew, Aregawi
Bekele, Tiruzer
Mesfin, Nebiyu
Ayalew, Mulugeta
Shiferaw, Elias
Hematological malignancies in the Northwest Ethiopia
title Hematological malignancies in the Northwest Ethiopia
title_full Hematological malignancies in the Northwest Ethiopia
title_fullStr Hematological malignancies in the Northwest Ethiopia
title_full_unstemmed Hematological malignancies in the Northwest Ethiopia
title_short Hematological malignancies in the Northwest Ethiopia
title_sort hematological malignancies in the northwest ethiopia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635328/
https://www.ncbi.nlm.nih.gov/pubmed/34852010
http://dx.doi.org/10.1371/journal.pone.0260639
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