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Persistent eczema leads to both impaired growth and food allergy: JECS birth cohort

Skin inflammation leads to altered cytokine/chemokine production and causes systemic inflammation. The systemic mechanism of atopic dermatitis (AD) is recognized to affect systemic metabolism. This study aimed to examine the relationship between early-onset persistent eczema and body weight, height,...

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Autores principales: Yamamoto-Hanada, Kiwako, Suzuki, Yuichi, Yang, Limin, Saito-Abe, Mayako, Sato, Miori, Mezawa, Hidetoshi, Nishizato, Minaho, Kato, Noriko, Ito, Yoshiya, Hashimoto, Koichi, Ohya, Yukihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635351/
https://www.ncbi.nlm.nih.gov/pubmed/34851995
http://dx.doi.org/10.1371/journal.pone.0260447
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author Yamamoto-Hanada, Kiwako
Suzuki, Yuichi
Yang, Limin
Saito-Abe, Mayako
Sato, Miori
Mezawa, Hidetoshi
Nishizato, Minaho
Kato, Noriko
Ito, Yoshiya
Hashimoto, Koichi
Ohya, Yukihiro
author_facet Yamamoto-Hanada, Kiwako
Suzuki, Yuichi
Yang, Limin
Saito-Abe, Mayako
Sato, Miori
Mezawa, Hidetoshi
Nishizato, Minaho
Kato, Noriko
Ito, Yoshiya
Hashimoto, Koichi
Ohya, Yukihiro
author_sort Yamamoto-Hanada, Kiwako
collection PubMed
description Skin inflammation leads to altered cytokine/chemokine production and causes systemic inflammation. The systemic mechanism of atopic dermatitis (AD) is recognized to affect systemic metabolism. This study aimed to examine the relationship between early-onset persistent eczema and body weight, height, and body mass index (BMI), in addition to food allergy in a birth cohort among infants. This study design was a nationwide, multicenter, prospective birth cohort study—the Japan Environment and Children’s Study (JECS). Generalized linear models were fitted for z scores of weight, height, BMI, and food allergy to evaluate the relationship between eczema and these outcomes for infants at age1, 2, and 3 years. Persistent eczema was negatively associated with height at the age of 2 years (estimated coefficient, −0.127; 95% confidence interval [CI], −0.16 to −0.095) and 3 years (−0.177; 95% CI, −0.214 to −0.139). The same tendency was also observed with weight and BMI. Early disease onset at younger than 1 year and persistent eczema had the strongest association with development of food allergy at age 3 years (OR, 11.794; 95% CI, 10.721–12.975). One phenotype of eczema with early-onset and persistent disease creates a risk of both physical growth impairment and development of food allergy. Infants who present with the early-onset and persistent type of eczema should be carefully evaluated daily for impaired physical growth and development of food allergy.
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spelling pubmed-86353512021-12-02 Persistent eczema leads to both impaired growth and food allergy: JECS birth cohort Yamamoto-Hanada, Kiwako Suzuki, Yuichi Yang, Limin Saito-Abe, Mayako Sato, Miori Mezawa, Hidetoshi Nishizato, Minaho Kato, Noriko Ito, Yoshiya Hashimoto, Koichi Ohya, Yukihiro PLoS One Research Article Skin inflammation leads to altered cytokine/chemokine production and causes systemic inflammation. The systemic mechanism of atopic dermatitis (AD) is recognized to affect systemic metabolism. This study aimed to examine the relationship between early-onset persistent eczema and body weight, height, and body mass index (BMI), in addition to food allergy in a birth cohort among infants. This study design was a nationwide, multicenter, prospective birth cohort study—the Japan Environment and Children’s Study (JECS). Generalized linear models were fitted for z scores of weight, height, BMI, and food allergy to evaluate the relationship between eczema and these outcomes for infants at age1, 2, and 3 years. Persistent eczema was negatively associated with height at the age of 2 years (estimated coefficient, −0.127; 95% confidence interval [CI], −0.16 to −0.095) and 3 years (−0.177; 95% CI, −0.214 to −0.139). The same tendency was also observed with weight and BMI. Early disease onset at younger than 1 year and persistent eczema had the strongest association with development of food allergy at age 3 years (OR, 11.794; 95% CI, 10.721–12.975). One phenotype of eczema with early-onset and persistent disease creates a risk of both physical growth impairment and development of food allergy. Infants who present with the early-onset and persistent type of eczema should be carefully evaluated daily for impaired physical growth and development of food allergy. Public Library of Science 2021-12-01 /pmc/articles/PMC8635351/ /pubmed/34851995 http://dx.doi.org/10.1371/journal.pone.0260447 Text en © 2021 Yamamoto-Hanada et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Yamamoto-Hanada, Kiwako
Suzuki, Yuichi
Yang, Limin
Saito-Abe, Mayako
Sato, Miori
Mezawa, Hidetoshi
Nishizato, Minaho
Kato, Noriko
Ito, Yoshiya
Hashimoto, Koichi
Ohya, Yukihiro
Persistent eczema leads to both impaired growth and food allergy: JECS birth cohort
title Persistent eczema leads to both impaired growth and food allergy: JECS birth cohort
title_full Persistent eczema leads to both impaired growth and food allergy: JECS birth cohort
title_fullStr Persistent eczema leads to both impaired growth and food allergy: JECS birth cohort
title_full_unstemmed Persistent eczema leads to both impaired growth and food allergy: JECS birth cohort
title_short Persistent eczema leads to both impaired growth and food allergy: JECS birth cohort
title_sort persistent eczema leads to both impaired growth and food allergy: jecs birth cohort
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635351/
https://www.ncbi.nlm.nih.gov/pubmed/34851995
http://dx.doi.org/10.1371/journal.pone.0260447
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