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Persistent eczema leads to both impaired growth and food allergy: JECS birth cohort
Skin inflammation leads to altered cytokine/chemokine production and causes systemic inflammation. The systemic mechanism of atopic dermatitis (AD) is recognized to affect systemic metabolism. This study aimed to examine the relationship between early-onset persistent eczema and body weight, height,...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635351/ https://www.ncbi.nlm.nih.gov/pubmed/34851995 http://dx.doi.org/10.1371/journal.pone.0260447 |
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author | Yamamoto-Hanada, Kiwako Suzuki, Yuichi Yang, Limin Saito-Abe, Mayako Sato, Miori Mezawa, Hidetoshi Nishizato, Minaho Kato, Noriko Ito, Yoshiya Hashimoto, Koichi Ohya, Yukihiro |
author_facet | Yamamoto-Hanada, Kiwako Suzuki, Yuichi Yang, Limin Saito-Abe, Mayako Sato, Miori Mezawa, Hidetoshi Nishizato, Minaho Kato, Noriko Ito, Yoshiya Hashimoto, Koichi Ohya, Yukihiro |
author_sort | Yamamoto-Hanada, Kiwako |
collection | PubMed |
description | Skin inflammation leads to altered cytokine/chemokine production and causes systemic inflammation. The systemic mechanism of atopic dermatitis (AD) is recognized to affect systemic metabolism. This study aimed to examine the relationship between early-onset persistent eczema and body weight, height, and body mass index (BMI), in addition to food allergy in a birth cohort among infants. This study design was a nationwide, multicenter, prospective birth cohort study—the Japan Environment and Children’s Study (JECS). Generalized linear models were fitted for z scores of weight, height, BMI, and food allergy to evaluate the relationship between eczema and these outcomes for infants at age1, 2, and 3 years. Persistent eczema was negatively associated with height at the age of 2 years (estimated coefficient, −0.127; 95% confidence interval [CI], −0.16 to −0.095) and 3 years (−0.177; 95% CI, −0.214 to −0.139). The same tendency was also observed with weight and BMI. Early disease onset at younger than 1 year and persistent eczema had the strongest association with development of food allergy at age 3 years (OR, 11.794; 95% CI, 10.721–12.975). One phenotype of eczema with early-onset and persistent disease creates a risk of both physical growth impairment and development of food allergy. Infants who present with the early-onset and persistent type of eczema should be carefully evaluated daily for impaired physical growth and development of food allergy. |
format | Online Article Text |
id | pubmed-8635351 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-86353512021-12-02 Persistent eczema leads to both impaired growth and food allergy: JECS birth cohort Yamamoto-Hanada, Kiwako Suzuki, Yuichi Yang, Limin Saito-Abe, Mayako Sato, Miori Mezawa, Hidetoshi Nishizato, Minaho Kato, Noriko Ito, Yoshiya Hashimoto, Koichi Ohya, Yukihiro PLoS One Research Article Skin inflammation leads to altered cytokine/chemokine production and causes systemic inflammation. The systemic mechanism of atopic dermatitis (AD) is recognized to affect systemic metabolism. This study aimed to examine the relationship between early-onset persistent eczema and body weight, height, and body mass index (BMI), in addition to food allergy in a birth cohort among infants. This study design was a nationwide, multicenter, prospective birth cohort study—the Japan Environment and Children’s Study (JECS). Generalized linear models were fitted for z scores of weight, height, BMI, and food allergy to evaluate the relationship between eczema and these outcomes for infants at age1, 2, and 3 years. Persistent eczema was negatively associated with height at the age of 2 years (estimated coefficient, −0.127; 95% confidence interval [CI], −0.16 to −0.095) and 3 years (−0.177; 95% CI, −0.214 to −0.139). The same tendency was also observed with weight and BMI. Early disease onset at younger than 1 year and persistent eczema had the strongest association with development of food allergy at age 3 years (OR, 11.794; 95% CI, 10.721–12.975). One phenotype of eczema with early-onset and persistent disease creates a risk of both physical growth impairment and development of food allergy. Infants who present with the early-onset and persistent type of eczema should be carefully evaluated daily for impaired physical growth and development of food allergy. Public Library of Science 2021-12-01 /pmc/articles/PMC8635351/ /pubmed/34851995 http://dx.doi.org/10.1371/journal.pone.0260447 Text en © 2021 Yamamoto-Hanada et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Yamamoto-Hanada, Kiwako Suzuki, Yuichi Yang, Limin Saito-Abe, Mayako Sato, Miori Mezawa, Hidetoshi Nishizato, Minaho Kato, Noriko Ito, Yoshiya Hashimoto, Koichi Ohya, Yukihiro Persistent eczema leads to both impaired growth and food allergy: JECS birth cohort |
title | Persistent eczema leads to both impaired growth and food allergy: JECS birth cohort |
title_full | Persistent eczema leads to both impaired growth and food allergy: JECS birth cohort |
title_fullStr | Persistent eczema leads to both impaired growth and food allergy: JECS birth cohort |
title_full_unstemmed | Persistent eczema leads to both impaired growth and food allergy: JECS birth cohort |
title_short | Persistent eczema leads to both impaired growth and food allergy: JECS birth cohort |
title_sort | persistent eczema leads to both impaired growth and food allergy: jecs birth cohort |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635351/ https://www.ncbi.nlm.nih.gov/pubmed/34851995 http://dx.doi.org/10.1371/journal.pone.0260447 |
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