Abnormal accumulation of lipid droplets in neurons induces the conversion of alpha-Synuclein to proteolytic resistant forms in a Drosophila model of Parkinson’s disease

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by alpha-synuclein (αSyn) aggregation and associated with abnormalities in lipid metabolism. The accumulation of lipids in cytoplasmic organelles called lipid droplets (LDs) was observed in cellular models of PD. To investigate t...

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Detalles Bibliográficos
Autores principales: Girard, Victor, Jollivet, Florence, Knittelfelder, Oskar, Celle, Marion, Arsac, Jean-Noel, Chatelain, Gilles, Van den Brink, Daan M., Baron, Thierry, Shevchenko, Andrej, Kühnlein, Ronald P., Davoust, Nathalie, Mollereau, Bertrand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635402/
https://www.ncbi.nlm.nih.gov/pubmed/34788284
http://dx.doi.org/10.1371/journal.pgen.1009921

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