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A neural circuit linking two sugar sensors regulates satiety-dependent fructose drive in Drosophila

In flies, neuronal sensors detect prandial changes in circulating fructose levels and either sustain or terminate feeding, depending on internal state. Here, we describe a three-part neural circuit that imparts satiety-dependent modulation of fructose sensing. We show that dorsal fan-shaped body neu...

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Autores principales: Musso, Pierre-Yves, Junca, Pierre, Gordon, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635442/
https://www.ncbi.nlm.nih.gov/pubmed/34851668
http://dx.doi.org/10.1126/sciadv.abj0186
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author Musso, Pierre-Yves
Junca, Pierre
Gordon, Michael D.
author_facet Musso, Pierre-Yves
Junca, Pierre
Gordon, Michael D.
author_sort Musso, Pierre-Yves
collection PubMed
description In flies, neuronal sensors detect prandial changes in circulating fructose levels and either sustain or terminate feeding, depending on internal state. Here, we describe a three-part neural circuit that imparts satiety-dependent modulation of fructose sensing. We show that dorsal fan-shaped body neurons display oscillatory calcium activity when hemolymph glucose is high and that these oscillations require glutamatergic input from SLP-AB or “Janus” neurons projecting from the protocerebrum to the asymmetric body. Suppression of activity in this circuit, either by starvation or by genetic silencing, promotes specific drive for fructose ingestion. This is achieved through neuropeptidergic signaling by tachykinin, which is released from the fan-shaped body when glycemia is high. Tachykinin, in turn, signals to Gr43a-positive fructose sensors to modulate their response to fructose. Together, our results demonstrate how a three-layer neural circuit links the detection of two sugars to produce precise satiety-dependent control of feeding behavior.
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spelling pubmed-86354422021-12-13 A neural circuit linking two sugar sensors regulates satiety-dependent fructose drive in Drosophila Musso, Pierre-Yves Junca, Pierre Gordon, Michael D. Sci Adv Neuroscience In flies, neuronal sensors detect prandial changes in circulating fructose levels and either sustain or terminate feeding, depending on internal state. Here, we describe a three-part neural circuit that imparts satiety-dependent modulation of fructose sensing. We show that dorsal fan-shaped body neurons display oscillatory calcium activity when hemolymph glucose is high and that these oscillations require glutamatergic input from SLP-AB or “Janus” neurons projecting from the protocerebrum to the asymmetric body. Suppression of activity in this circuit, either by starvation or by genetic silencing, promotes specific drive for fructose ingestion. This is achieved through neuropeptidergic signaling by tachykinin, which is released from the fan-shaped body when glycemia is high. Tachykinin, in turn, signals to Gr43a-positive fructose sensors to modulate their response to fructose. Together, our results demonstrate how a three-layer neural circuit links the detection of two sugars to produce precise satiety-dependent control of feeding behavior. American Association for the Advancement of Science 2021-12-01 /pmc/articles/PMC8635442/ /pubmed/34851668 http://dx.doi.org/10.1126/sciadv.abj0186 Text en Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Neuroscience
Musso, Pierre-Yves
Junca, Pierre
Gordon, Michael D.
A neural circuit linking two sugar sensors regulates satiety-dependent fructose drive in Drosophila
title A neural circuit linking two sugar sensors regulates satiety-dependent fructose drive in Drosophila
title_full A neural circuit linking two sugar sensors regulates satiety-dependent fructose drive in Drosophila
title_fullStr A neural circuit linking two sugar sensors regulates satiety-dependent fructose drive in Drosophila
title_full_unstemmed A neural circuit linking two sugar sensors regulates satiety-dependent fructose drive in Drosophila
title_short A neural circuit linking two sugar sensors regulates satiety-dependent fructose drive in Drosophila
title_sort neural circuit linking two sugar sensors regulates satiety-dependent fructose drive in drosophila
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635442/
https://www.ncbi.nlm.nih.gov/pubmed/34851668
http://dx.doi.org/10.1126/sciadv.abj0186
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