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Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults
Background: Uromodulin, also named Tamm Horsfall protein, has been associated with renal function and regulation of sodium homeostasis. We aimed to examine the associations of serum uromodulin levels and its genetic variants with longitudinal blood pressure (BP) changes and hypertension incidence/ri...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635522/ https://www.ncbi.nlm.nih.gov/pubmed/34869624 http://dx.doi.org/10.3389/fcvm.2021.710023 |
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author | Wang, Yang Du, Ming-Fei Yao, Shi Zou, Ting Zhang, Xiao-Yu Hu, Gui-Lin Chu, Chao Liao, Yue-Yuan Chen, Chen Wang, Dan Ma, Qiong Wang, Ke-Ke Sun, Yue Niu, Ze-Jiaxin Yan, Rui-Chen Yan, Yu Zhou, Hao-Wei Jia, Hao Gao, Wei-Hua Li, Hao Li, Chun-Hua Chen, Fang-Yao Gao, Ke Zhang, Jie Safirstein, Robert Wang, Feng Yang, Tie-Lin Mu, Jian-Jun |
author_facet | Wang, Yang Du, Ming-Fei Yao, Shi Zou, Ting Zhang, Xiao-Yu Hu, Gui-Lin Chu, Chao Liao, Yue-Yuan Chen, Chen Wang, Dan Ma, Qiong Wang, Ke-Ke Sun, Yue Niu, Ze-Jiaxin Yan, Rui-Chen Yan, Yu Zhou, Hao-Wei Jia, Hao Gao, Wei-Hua Li, Hao Li, Chun-Hua Chen, Fang-Yao Gao, Ke Zhang, Jie Safirstein, Robert Wang, Feng Yang, Tie-Lin Mu, Jian-Jun |
author_sort | Wang, Yang |
collection | PubMed |
description | Background: Uromodulin, also named Tamm Horsfall protein, has been associated with renal function and regulation of sodium homeostasis. We aimed to examine the associations of serum uromodulin levels and its genetic variants with longitudinal blood pressure (BP) changes and hypertension incidence/risk. Methods: A total of 514 participants from the original Baoji Salt-Sensitive Study cohort were genotyped to examine the associations of genetic variations in uromodulin gene with the longitudinal BP changes and the incidence of hypertension over 8 years of follow-up. In addition, 2,210 subjects from the cohort of Hanzhong Adolescent Hypertension Study were used to investigate the relationships between serum uromodulin levels and the risk of hypertension. Results: SNPs rs12917707 and rs12708631 in the uromodulin gene were significantly associated with the longitudinal BP changes over 8 years of follow-up. SNP rs12708631 was significantly associated with the incidence of hypertension over 8 years. In addition, gene-based analyses supported the associations of uromodulin gene with the longitudinal BP changes and hypertension incidence in Baoji Salt-Sensitive Study cohort. Furthermore, serum uromodulin levels in the hypertensive subjects were lower than in the normotensive subjects (25.5 ± 1.1 vs. 34.7 ± 0.7 ng/mL). Serum uromodulin levels decreased gradually as BP levels increased (34.6, 33.2, 27.8, and 25.0 ng/mL for subjects with normotension, high-normal, grade 1 hypertension, and grade 2 hypertension, respectively). Serum uromodulin was significantly associated with the lower risk of hypertension [0.978 (0.972–0.984)] in Hanzhong Adolescent Hypertension Study cohort. Conclusion: This study shows that uromodulin is associated with blood pressure progression and development of hypertension. |
format | Online Article Text |
id | pubmed-8635522 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-86355222021-12-02 Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults Wang, Yang Du, Ming-Fei Yao, Shi Zou, Ting Zhang, Xiao-Yu Hu, Gui-Lin Chu, Chao Liao, Yue-Yuan Chen, Chen Wang, Dan Ma, Qiong Wang, Ke-Ke Sun, Yue Niu, Ze-Jiaxin Yan, Rui-Chen Yan, Yu Zhou, Hao-Wei Jia, Hao Gao, Wei-Hua Li, Hao Li, Chun-Hua Chen, Fang-Yao Gao, Ke Zhang, Jie Safirstein, Robert Wang, Feng Yang, Tie-Lin Mu, Jian-Jun Front Cardiovasc Med Cardiovascular Medicine Background: Uromodulin, also named Tamm Horsfall protein, has been associated with renal function and regulation of sodium homeostasis. We aimed to examine the associations of serum uromodulin levels and its genetic variants with longitudinal blood pressure (BP) changes and hypertension incidence/risk. Methods: A total of 514 participants from the original Baoji Salt-Sensitive Study cohort were genotyped to examine the associations of genetic variations in uromodulin gene with the longitudinal BP changes and the incidence of hypertension over 8 years of follow-up. In addition, 2,210 subjects from the cohort of Hanzhong Adolescent Hypertension Study were used to investigate the relationships between serum uromodulin levels and the risk of hypertension. Results: SNPs rs12917707 and rs12708631 in the uromodulin gene were significantly associated with the longitudinal BP changes over 8 years of follow-up. SNP rs12708631 was significantly associated with the incidence of hypertension over 8 years. In addition, gene-based analyses supported the associations of uromodulin gene with the longitudinal BP changes and hypertension incidence in Baoji Salt-Sensitive Study cohort. Furthermore, serum uromodulin levels in the hypertensive subjects were lower than in the normotensive subjects (25.5 ± 1.1 vs. 34.7 ± 0.7 ng/mL). Serum uromodulin levels decreased gradually as BP levels increased (34.6, 33.2, 27.8, and 25.0 ng/mL for subjects with normotension, high-normal, grade 1 hypertension, and grade 2 hypertension, respectively). Serum uromodulin was significantly associated with the lower risk of hypertension [0.978 (0.972–0.984)] in Hanzhong Adolescent Hypertension Study cohort. Conclusion: This study shows that uromodulin is associated with blood pressure progression and development of hypertension. Frontiers Media S.A. 2021-11-17 /pmc/articles/PMC8635522/ /pubmed/34869624 http://dx.doi.org/10.3389/fcvm.2021.710023 Text en Copyright © 2021 Wang, Du, Yao, Zou, Zhang, Hu, Chu, Liao, Chen, Wang, Ma, Wang, Sun, Niu, Yan, Yan, Zhou, Jia, Gao, Li, Li, Chen, Gao, Zhang, Safirstein, Wang, Yang and Mu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Wang, Yang Du, Ming-Fei Yao, Shi Zou, Ting Zhang, Xiao-Yu Hu, Gui-Lin Chu, Chao Liao, Yue-Yuan Chen, Chen Wang, Dan Ma, Qiong Wang, Ke-Ke Sun, Yue Niu, Ze-Jiaxin Yan, Rui-Chen Yan, Yu Zhou, Hao-Wei Jia, Hao Gao, Wei-Hua Li, Hao Li, Chun-Hua Chen, Fang-Yao Gao, Ke Zhang, Jie Safirstein, Robert Wang, Feng Yang, Tie-Lin Mu, Jian-Jun Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults |
title | Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults |
title_full | Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults |
title_fullStr | Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults |
title_full_unstemmed | Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults |
title_short | Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults |
title_sort | associations of serum uromodulin and its genetic variants with blood pressure and hypertension in chinese adults |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635522/ https://www.ncbi.nlm.nih.gov/pubmed/34869624 http://dx.doi.org/10.3389/fcvm.2021.710023 |
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