A click chemistry approach to pleuromutilin derivatives, evaluation of anti-MRSA activity and elucidation of binding mode by surface plasmon resonance and molecular docking

Novel series of pleuromutilin analogs containing substituted 1,2,3-triazole moieties were designed, synthesised and assessed for their in vitro antibacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA). Initially, the in vitro antibacterial activities of these derivatives aga...

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Detalles Bibliográficos
Autores principales: Zhang, Zhe, Zhang, Zhao-Sheng, Wang, Xiao, Xi, Gao-Lei, Jin, Zhen, Tang, You-Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8635623/
https://www.ncbi.nlm.nih.gov/pubmed/34823417
http://dx.doi.org/10.1080/14756366.2021.1977931

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